Neuromuscular Blocking Agents Utilized During Perioperative Hypersensitivity Evaluation
- Conditions
- Allergy
- Registration Number
- NCT04046731
- Lead Sponsor
- Mayo Clinic
- Brief Summary
The researchers are trying to develop an allergy skin test to help predict allergic responses to medications commonly given to patients during surgery.
- Detailed Description
This study will be a prospective study to accurately determine the negative predictive value of skin testing with NMBAs.
It is hypothesized that the concentrations that should be used for NMBAs are actually much lower than previously recommended and that the higher incidence of identifiable NMBA induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 187
- All adults > or = to 18 y/o undergoing surgery
- Minors under the age of 18 y/o, Adults unable to consent, or those Adults with previous allergic reaction history during previous surgeries.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Non-Irritant Concentrations to common NMBAs 1 Year Determine the NIC to common NMBAs
- Secondary Outcome Measures
Name Time Method Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs 1 Year Determine Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs
Max Concentration used when skin testing to NMBAs 1 Year Close gap on the variability of the maximal concentration used when skin testing NMBAs.
Trial Locations
- Locations (1)
Mayo Clinic
🇺🇸Jacksonville, Florida, United States
Mayo Clinic🇺🇸Jacksonville, Florida, United States