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Neuromuscular Blocking Agents Utilized During Perioperative Hypersensitivity Evaluation

Not Applicable
Completed
Conditions
Allergy
Registration Number
NCT04046731
Lead Sponsor
Mayo Clinic
Brief Summary

The researchers are trying to develop an allergy skin test to help predict allergic responses to medications commonly given to patients during surgery.

Detailed Description

This study will be a prospective study to accurately determine the negative predictive value of skin testing with NMBAs.

It is hypothesized that the concentrations that should be used for NMBAs are actually much lower than previously recommended and that the higher incidence of identifiable NMBA induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
187
Inclusion Criteria
  • All adults > or = to 18 y/o undergoing surgery
Exclusion Criteria
  • Minors under the age of 18 y/o, Adults unable to consent, or those Adults with previous allergic reaction history during previous surgeries.

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Primary Outcome Measures
NameTimeMethod
Non-Irritant Concentrations to common NMBAs1 Year

Determine the NIC to common NMBAs

Secondary Outcome Measures
NameTimeMethod
Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs1 Year

Determine Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs

Max Concentration used when skin testing to NMBAs1 Year

Close gap on the variability of the maximal concentration used when skin testing NMBAs.

Trial Locations

Locations (1)

Mayo Clinic

🇺🇸

Jacksonville, Florida, United States

Mayo Clinic
🇺🇸Jacksonville, Florida, United States

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