NCT04046731已完成不适用
The Negative Predictive Value and Non-irritant Skin Testing Concentrations of Neuromuscular Blocking Agents Utilized During Perioperative Hypersensitivity Evaluation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 187
- 试验地点
- 2
- 主要终点
- Non-Irritant Concentrations to common NMBAs
研究概览
简要总结
The researchers are trying to develop an allergy skin test to help predict allergic responses to medications commonly given to patients during surgery.
详细描述
This study will be a prospective study to accurately determine the negative predictive value of skin testing with NMBAs.
It is hypothesized that the concentrations that should be used for NMBAs are actually much lower than previously recommended and that the higher incidence of identifiable NMBA induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adults > or = to 18 y/o undergoing surgery
排除标准
- •Minors under the age of 18 y/o, Adults unable to consent, or those Adults with previous allergic reaction history during previous surgeries.
结局指标
主要结局
Non-Irritant Concentrations to common NMBAs
时间窗: 1 Year
Determine the NIC to common NMBAs
次要结局
- Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs(1 Year)
- Max Concentration used when skin testing to NMBAs(1 Year)
研究者
Alexei Gonzalez-Estrada, MD
Principal Investigator
Mayo Clinic
研究点 (2)
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