Clinical study on improving the activity endurance of Gubenquyujiedu formula in patients with chronic obstructive pulmonary disease

Not Applicable

• Conditions: chronic obstructive pulmonary disease

• Registration Number: ITMCTR2200006070
• Lead Sponsor: Xiyuan Hospital of China Academy of Chinese Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

(1) Patients with AECOPD with grade I or II disease.
(2) Patients with TCM evidence of stasis and toxin blockage.
(3) The number of acute exacerbations of COPD in the past two years > 1 time/year.
(4) 20 years old = age = 80 years old.
(5) Voluntarily accept the treatment and sign the informed consent form.

Exclusion Criteria

(1) Patients with combined asthma, impaired consciousness, pneumonia, tuberculosis, pleural effusion, malignancy and hematological disorders.
(2) Patients with severe impairment of cardiac, hepatic and renal functions (cardiac function grade 3-4, ALT and/or AST more than 1.5 times the upper limit of normal, Cr more than the upper limit of normal).
(3) Suffering from mental illness, cardiovascular and cerebrovascular thrombotic diseases.
(4) Persons with congenital or acquired immunodeficiency.
(5) Those with known allergy to therapeutic drugs.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
HIF-1a;VEGF;BODE Score;miRNA-199a-5p;miRNA-1-3p;6MWT;Blood gas analysis;Lung function;CAT Questionnaire;Quantitative scoring of TCM evidence;IL-8;