Comparison of Amisulpride vs Ondansetron in the prophylaxis of Post Operative Nausea and Vomiting in abdominal surgeries: a randomized controlled study.

Presently dopamine (D2), serotonin (5-HT3), and histamine (H1) antagonists are widely used prophylactic agents, as is the corticosteroid dexamethasone, but the incidence of postoperative nausea and vomiting (PONV) is still appreciable. Safety concerns as QT interval prolongation has led to nearly phasing out of use of D2-antagonist Droperidol, a potent and most favoured formulation. With minimal studies and randomized studies to back up the efficacy of existing modalities viz 5HT-antagonist, promethazine, metoclopramide and dimenhydrinate for management of postoperative nausea and vomiting, need for evaluation, study and incorporation into formulary for management was always persisting.[ 3]

Amisulpride is an anti-psychotic agent, used routinely are a potent but atypical D2-antagonist with minimal adverse profile mainly QT interval prolongation, as compared to ondansetron extrapyramidal signs and symptoms, which had plagued out other members of same class. In addition to D2 antagonism this

drug exhibits potent antagonist action against D3 receptors, implicated in the emetic response. In pre-clinical studies and multiple randomized controlled multicentre studies, the effectiveness and safety of low dose intra venous the purpose of this study is To study effects on post operative nausea and vomiting in patients receiving amisulpride 5mg  and compare it with patients receiving 4mg of ondansetron using apfel score and koivuranta nausea and vomiting total score