EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION
- Conditions
- Infection
- Interventions
- Other: blood sample
- Registration Number
- NCT02917486
- Lead Sponsor
- Rennes University Hospital
- Brief Summary
The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation.
The exhibition is evaluated by population pharmacokinetic modeling.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Age over 18 years
- Hospitalisation in intensive care
- Treatment with ECMO or without ECMO
- Introducing sepsis treated with an anti-infective molecule studied (piperacillin) for less than 48 hours
- With an arterial catheter
- Patient Information or their next of kin according to the patients status.
Exclusion Criteria
- Pregnancy
- Major person under legal protection (backup justice, trusteeship, quardianship), person deprived of liberty
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description ECMO piperacillin blood sample patients in intensive care treated with ECMO with antiinfective therapy : piperacillin without ECMO piperacillin blood sample patients in intensive care without ECMO with antiinfective therapy : piperacillin
- Primary Outcome Measures
Name Time Method Measure exposure to piperacillin Day 1 evaluated by population pharmacokinetic modeling and is defined by the time during which the antibiotic concentration is greater than 4 times the critical concentration of the germ to treat
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Rennes
🇫🇷Rennes, France