PREOPERATIVE CHEMOTHERAPY DOES NOT ADVERSELY AFFECT SHORT-TERM OUTCOME AFTER PANCREATIC RESECTION.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Postoperative morbidity rate
研究概览
简要总结
No comparative trial investigating the effect of preoperative chemotherapy for locally advanced pancreatic cancer on short-term postoperative outcome has been published so far. The aim of the present study is to assess the potential impact of preoperative chemotherapy on short-term postoperative outcome after pancreatic resection in a case-matched series of cancer patients.
详细描述
Between 2003 and 2011, patients with locally advanced (stage III) pancreatic cancer who were treated with preoperative chemotherapy (PCHT) underwent surgical resection. Each patient was matched with the closest two patients with pancreatic cancer ( control group ) selected from our prospective electronic database who met the following match criteria: age (+/- 3 years), gender, ASA score, type of resection, pancreatic duct diameter (+/- 1 mm), and tumour size (+/- 5 mm).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of pancreatic cancer
- •Preoperative chemotherapy
- •Pancreatic resection
排除标准
- •Metastatic disease
- •ASA score 4
研究组 & 干预措施
Preoperative chemotherapy (PCHT)
Patients who underwent pancreatic resection after PCHT.
干预措施: Pancreatic resection after preoperative chemotherapy (Procedure)
Control
Patient who underwent pancreatic resection without preoperative therapy
干预措施: Pancreatic resection (Procedure)
结局指标
主要结局
Postoperative morbidity rate
时间窗: Postoperative. From 0 to 30 days after discharge
次要结局
- Postoperative mortality(Postoperative. From 0 to 30 days after discharge)
- Length of hospital stay (LOS)(Postoperative. From 0 to 30 days after discharge)
研究者
Marco Braga
Associate Professor of Surgery
Università Vita-Salute San Raffaele