PREoxygenation for the Intubation of Hypoxemic Patients: Comparison of Standard Oxygenation, High Flow Nasal Oxygen Therapy, and NonInvasive Ventilation

University Hospital, Clermont-Ferrand1 site in 1 country132 target enrollmentApril 2015

ConditionsAdult Patients Requiring Intubation Hypoxemia (Defined by PaO2/FiO2( Fraction of Inspired Oxygen) Below 200)Patient Covered by French Health Care System

Overview

Phase: Phase 2
Intervention: Not specified
Conditions: Adult Patients
Sponsor: University Hospital, Clermont-Ferrand
Enrollment: 132
Locations: 1
Primary Endpoint: least pulse oxymetry value
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Prospective, randomized clinical multicentric study, in ICU, during preoxygenation for the intubation of hypoxemic patients.

Detailed Description

Prospective randomized clinical multicentric study in ICU, comparing standard oxygenation, high flow nasal oxygen therapy and non invasive ventilation (NIV) , with pulse oxymetry values (SpO2), during preoxygenation for hypoxemic patients

Registry

clinicaltrials.gov

Start Date

April 2015

End Date

September 2016

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University Hospital, Clermont-Ferrand

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•adults patients
•requiring intubation and hypoxemia (defined by PaO2/FiO2 below 200)
•patient covered by french health care system

Exclusion Criteria

•patient refusal
•intubation for other causes (excluding hypoxemia)
•impossibility to measure pulse oxymetry value
•contraindication for NIV : vomiting
•NIV intolerance
•cardiac arrest during intubation

Outcomes

Primary Outcomes

least pulse oxymetry value

Time Frame: at day 1

Secondary Outcomes

Partial pressure of arterial oxygen (PaO2)(at day 1)
oxyhemoglobin desaturation below 80 %(at day 1)
pulse oxymetry value (at the end of preoxygenation)(at 5 minutes and at 30 minutes after intubation)
Regurgitation rate(at day 1)