Problems of Measurement and Evaluation of Breathing Effort in Spontaneously Breathing Subjects
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- iPTP
研究概览
简要总结
The aim of the research project is to evaluate the breathing effort using the Work of Breathing (WoB) and Pressure-Time Product (PTP) parameters, depending on the increasing flow resistance. The research project is concerned with assessing the increased (imposed) breathing effort using the Work of Breathing (iWoB) and the Pressure-Time Product (iPTP).
The main hypothesis tested is the differential effect of flow resistance on iWoB and iPTP parameters in spontaneous breathing of healthy probands.
详细描述
Due to the different calculation of iWoB and iWoB, these parameters may be affected at higher flow resistance values. The proposed experiment will be used to compare iWoB and iPTP obtained during spontaneous breathing to healthy subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
No masking will be done
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy males and females > 18 and < 40 years old
- •Signed informed consent has been obtained
排除标准
- •Respiratory disease
- •Pregnancy
- •Cardiovascular disease
- •Diabetes mellitus
研究组 & 干预措施
Breathing through a system with adjustable flow resistance
During the experiment, the volunteers will breathe through ten adjustable flow resistances and their work of breathing will be measured.
干预措施: Breathing through a system with adjustable flow resistance (Device)
结局指标
主要结局
iPTP
时间窗: through study completion, an average of 1 year
imposed pressure time product in Pa.s/L
iWoB
时间窗: through study completion, an average of 1 year
imposed work of breathing in J/s/L
次要结局
未报告次要终点