Problems of Measurement and Evaluation of Breathing Effort in Spontaneously Breathing Subjects
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Czech Technical University in Prague
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- iWoB
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of the research project is to evaluate the breathing effort using the Work of Breathing (WoB) and Pressure-Time Product (PTP) parameters, depending on the increasing flow resistance. The research project is concerned with assessing the increased (imposed) breathing effort using the Work of Breathing (iWoB) and the Pressure-Time Product (iPTP).
The main hypothesis tested is the differential effect of flow resistance on iWoB and iPTP parameters in spontaneous breathing of healthy probands.
Detailed Description
Due to the different calculation of iWoB and iWoB, these parameters may be affected at higher flow resistance values. The proposed experiment will be used to compare iWoB and iPTP obtained during spontaneous breathing to healthy subjects.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy males and females \> 18 and \< 40 years old
- •Signed informed consent has been obtained
Exclusion Criteria
- •Respiratory disease
- •Pregnancy
- •Cardiovascular disease
- •Diabetes mellitus
Outcomes
Primary Outcomes
iWoB
Time Frame: through study completion, an average of 1 year
imposed work of breathing in J/s/L
iPTP
Time Frame: through study completion, an average of 1 year
imposed pressure time product in Pa.s/L