The Effect of Steep Trendelenburg Position on Neurocognitive Functions in Robotic Radical Prostatectomy Cases

Not yet recruiting

• Conditions: Neurocognitive Disorder; Robotic Assisted Laparoscopic Radical Prostatectomy; Near Infrared Spectroscopy

• Registration Number: NCT06869304
• Lead Sponsor: Ankara City Hospital Bilkent

Brief Summary

The aim of this study is to evaluate the effects of the steep Trendelenburg position in robotic prostatectomy cases, where anesthesia depth is monitored using BIS and cerebral perfusion is tracked with NIRS, and to determine the incidence of neurocognitive dysfunction using the MoCA test in the postoperative period.

Steep Trendelenburg position and CO₂ pneumoperitoneum during robotic radical prostatectomy lead to significant changes in intracranial pressure and cerebral oxygenation, which may contribute to postoperative neurocognitive dysfunction (POCD). Monitoring anesthesia depth with Bispectral Index (BIS) and cerebral perfusion with Near-Infrared Spectroscopy (NIRS) may help detect early neurocognitive changes, and MoCA test assessments will reveal a measurable decline in cognitive function postoperatively.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-04
• Study First Submitted QC: 2025-03-10
• Last Update Submitted: 2025-03-10
• Study First Posted: 2025-03-11
• Last Update Posted: 2025-03-11
• Study Start: 2025-03-15
• Primary Completion: 2025-04-15
• Study Completion: 2025-10-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Male
• Target Recruitment: 56

Inclusion Criteria

• Age ≥ 65 years
• ASA II-III risk score
• Patients scheduled for robotic radical prostatectomy
• Patients who voluntarily agree to participate

Exclusion Criteria

• Age < 65 years
• History of neurological or psychiatric disorders
• Inability to undergo robotic surgery
• Conversion to open prostatectomy during surgery
• Patients who do not consent to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MoCA	day 1	postoperative MoCA test scores

Secondary Outcome Measures

Name	Time	Method
NIRS	intraoperatively	NIRS values (right \& left)

Trial Locations

Locations (1)

Ankara City Hospital Bilkent; 🇹🇷 Ankara, Turkey