New Psychoactive Substances in Intoxicated Patients During the Winter Activities

Completed

• Conditions: Acute Intoxication; Psychoactive Substance Use
• Interventions: Other: urine analysis

• Registration Number: NCT04155281
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

The purpose of this research is to identify the New Psychoactive Substances (NPS) that are responsible for intoxicating patients in ski resort during winter activities.

Detailed Description

The New Psychoactive Substances expose to an additional risk of overdose or death due to their potency. These New Psychoactive Substances are used voluntarily by users wishing to test new substances, but also involuntarily because of association (unknowingly users) with more "conventional" drugs such as cocaine or heroin in the self-administered powder. These intoxications are still poorly known and the investigators believe that the identification of New Psychoactive Substances among the drugs consumed, and the association of their consumption with the appearance of a particular symptomatology allow the physician to guide the diagnosis and facilitate the care of future patients.

Study Timeline

• Study First Submitted: 2019-09-27
• Study First Submitted QC: 2019-11-04
• Study First Posted: 2019-11-07
• Study Start: 2020-01-23
• Primary Completion: 2023-06-30
• Study Completion: 2023-10-30
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-28
• Last Update Posted: 2023-11-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 87

Inclusion Criteria

• Admission to emergency, resuscitation or intensive care departments involved in the study
• Anamnestic and / or clinical suspicion of acute drug poisoning according to International Classification of Diseases-10 criteria
• Patient coming from a ski resort from the pre-established list
• urine sample available as part of the treatment
• person understanding French or English
• Non-opposition to the study

Exclusion Criteria

• Suspicion of alcohol intoxication alone
• Suspicion of voluntary drug poisoning
• Suspicion of intentional intoxication by others
• Pregnant or breastfeeding women
• Major mentioned in Articles L1121-6 and 1121-8 of french public health code
• Patients in the exclusion period of another research involving the human person type 1 or 2

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
suspicion of intoxication	urine analysis	New Psychoactive Substances research in urine

Primary Outcome Measures

Name	Time	Method
positive urinary sample	Day 0	proportion of urine samples positive for New Psychoactive Substances and related, among patients suspected of intoxication and from a ski resort, in winter.

Secondary Outcome Measures

Name	Time	Method
polyintoxication frequency	baseline	Percentage of co-intoxications
incidence of toxidromes	baseline	Clinical symptoms observed in intoxicated patients
morbidity of intoxication	baseline and month 1	Percentage of Intensive Care Unit admissions
incidence of intoxication medical care	day 1	names of therapies implemented within 24 hours of admission

Trial Locations

Locations (3)

Centre Hospitalier Métropole Savoie (Chaméry); 🇫🇷 Chambéry, Savoie, France

CH Albertville Moutiers; 🇫🇷 Albertville, France

University Hospital Grenoble; 🇫🇷 Grenoble, France