Abuse and Addiction in ICU
- Conditions
- Substance Withdrawal Syndrome
- Interventions
- Other: AUDIT-COther: Smoking historyOther: Prior psychotropic medication use
- Registration Number
- NCT02951793
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Investigators are seeking to determine the impact of recent alcohol, smoking or psychotropic drug use prior to intensive care unit (ICU) admission on incidence of delirium and sedation requirements.
Study design: A prospective observational study, in a medical ICU of a tertiary university hospital.
Methods: For all new ICU admissions, a 1-page questionnaire including Alcohol Use Disorders Identification Test (AUDIT-C), smoking history and prior medication use was given to the patient or closest family members.
Delirium was assessed by trained ICU nurses using Intensive Care Delirium Screening Checklist and Richmond Agitation-Sedation Scale.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- Patients who are older than 18 years of age
- New patients admitted to medical ICU for the 1st time during their stay in hospital
- Had history of stroke or other primary neurologic disease
- GCS ≤ 8 prior to ICU admission
- Transferred from other ICU (except for emergency ICU stay which is limited to less than 36 hours)
- Not registered within 24 hours after admission
- Refused to participate
- If comatous state persists
- Delirium assessment is not possible due to newly developed neurologic disease, such as cerebral infarction
- Medical ICU stay less than 24 hours
- Readmission to medical ICU
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description AUDIT-C > 4 AUDIT-C Significant alcohol use within 1 year prior to ICU admission (AUDIT-C\>4) Smoking history positive last year Smoking history Who smoke cigarette within 1-year prior to ICU admission Prior psychotropic medication use - no Prior psychotropic medication use Who did not use psychotropic medication within 1-year prior to ICU admission Smoking history negative last year Smoking history Who did not smoke cigarette within 1-year prior to ICU admission Prior psychotropic medication use - yes Prior psychotropic medication use Who used psychotropic medication within 1-year prior to ICU admission AUDIT-C <=4 AUDIT-C No significant alcohol use within 1 year prior to ICU admission (AUDIT-C: equal or less than 4)
- Primary Outcome Measures
Name Time Method Delirium during ICU stay From date of ICU admission until the date of ICU discharge, whichever came first, assessed up to 3 months
- Secondary Outcome Measures
Name Time Method ICU length of stay From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months Mortality From date of ICU admission until the date of death, assessed up to 3 months Death in MICU
Maximal doses of dexmedetomidine From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months Cumulative dose of dexmedetomidine From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months Cumulative dose of dexmedetomidine during the patient's MICU stay
Cumulative dose of midazolam From date of ICU admission until the date of first documented discharge from ICU or death, whichever came first, assessed up to 3 months Cumulative dose of midazolam during the patient's MICU stay
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of