A comparative study to evaluate the effect of dexmedetomidine in 2% lignocaine hydrochloride vs adrenaline in 2% lignocaine hydrochloride for extraction of maxillary molars by the infiltration technique.â€

Not yet recruiting

• Conditions: Dental caries, unspecified, (2) ICD-10 Condition: K029||Dental caries, unspecified,

• Registration Number: CTRI/2020/04/024468
• Lead Sponsor: Self funding

Brief Summary

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|Local anesthetic with an optimal duration of action, good analgesia, and negligible toxicity is an optimal choice for removal of tooth   Local anaesthetics alone are less profound and suffer the limitation of a short duration of action as compared to local anaesthetics with adjuvant. The adjuvant are co–administered with the local anaesthetic agents to improve the onset and/or duration of analgesia which include both opioids and non-opioids, including epinephrine and an α2 agonist. . A common standard option is Lignocaine hydrochloride 2% with Adrenaline (1:80,000).Adrenaline is one of the most commonly used adjuvant with lidocaine or any other anaesthetic agent. The predominant action of epinephrine is on β receptors; however, it also affects α receptors. Although potency of ADRENALINE containing dental local anaesthesia is clearly demonstrated to be superior to a plain anaesthetic solution i.e. Without a vasoconstrictor.

Nevertheless plain local anaesthetics still preferred for patients with co morbidities like circulatory disorder to avoid complications and adverse systemic effects of vasoconstrictors.Continued search of an ideal adjuvant led the researchers to use a newer member of alpha agonist family “dexmedetomidineâ€.Dexmedetomidine has been proved in literature as 1620 times selective for alpha 2 receptors and moreover is associated with stable hemodynamics when compared to other adjutants. The drug acts by binding to the presynaptic α-adrenoreceptors which results in the inhibition of release of epinephrine leading to termination of propagation of pain signals. However research studies have only recently focused on this newer drug for its use as a possible additive for local anaesthesia.

objective:-

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|. Effects of dexmedetomidine (30 μg)  with 2% lignocaine hydrochloride in maxillary infiltration anesthesia for the extraction of maxillary molar teeth.

2. Effects of adrenaline (1:80,000) with 2% lignocaine hydrochloride in maxillary infiltration anesthesia for the extraction of maxillary molar teeth

3. Compare effects of dexmedetomidine (30 μg) with 2% lignocaine hydrochloride versus adrenaline (1:80,000) with 2% lignocaine hydrochloride in maxillary infiltration anesthesia for the extraction of maxillary molar teeth.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-03-04
• Study Start: 2020-04-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients willing to participate in the study This study will included patients between 18-60yr Teeth diagnosed with dental caries, teeth which could not be restored and patients who refused conservative management will be included in the study.
• patients requiring bilateral orthodontic extraction.

Exclusion Criteria

• Patients with complains of morbidities such as hypertension, diabetes mellitus, asthma, bleeding disorders.
• Patient who have known allergies to any drug under study.
• Pregnant women, nursing mothers and apprehensive patients will be excluded from the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hemodynamic parameters among the both group An observer will be monitored all the patient for Heart Rate (HR) Systolic Blood Pressure (SBP)Diastolic Blood Pressure (DBP)Mean Arterial Pressure (MAP).	Hemodynamic parameters among the both group An observer will be monitored all the patient for Heart Rate (HR) Systolic Blood Pressure (SBP)Diastolic Blood Pressure (DBP)Mean Arterial Pressure (MAP).

Secondary Outcome Measures

Name	Time	Method
Intensity of anesthesia	Duration of anesthesia

Trial Locations

Locations (1)

Terna dental college; 🇮🇳 Thane, MAHARASHTRA, India

Terna dental college

🇮🇳Thane, MAHARASHTRA, India

Apurva Vaidya

Principal investigator

08767755863

apurva.vaidya0@gmail.com