Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity

Phase 2

Active, not recruiting

• Conditions: Pre Diabetes
• Interventions: Other: Hyperinsulemic euglycemic clamp; Procedure: Muscle Biopsy; Other: Placebo; Dietary Supplement: Oral abscisic acid (ABA)

• Registration Number: NCT04722354
• Lead Sponsor: AdventHealth Translational Research Institute

Brief Summary

The purpose of this study is to determine the effects of oral abscisic acid (ABA) on glucose metabolism in subjects with defined prediabetes.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-01-08
• Study First Submitted QC: 2021-01-20
• Study First Posted: 2021-01-25
• Study Start: 2021-03-08
• Primary Completion: 2024-08-26
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-12
• Last Update Posted: 2025-03-13
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo group	Hyperinsulemic euglycemic clamp	Corn Starch 300 mg for 14 days
ABA group	Hyperinsulemic euglycemic clamp	95 ug 2x/day for 14 days
Placebo group	Placebo	Corn Starch 300 mg for 14 days
ABA group	Oral abscisic acid (ABA)	95 ug 2x/day for 14 days
Placebo group	Muscle Biopsy	Corn Starch 300 mg for 14 days
ABA group	Muscle Biopsy	95 ug 2x/day for 14 days

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	4-6 hours	Insulin sensitivity will be measured using hyperinsulinic euglycemic clamp
Monitoring adverse events	10 weeks	Adverse events will be monitored at each visit throughout the duration of the study.

Trial Locations

Locations (1)

AdventHealth Translational Research Institute; 🇺🇸 Orlando, Florida, United States