The Effects of L-arabinose in a Meal in Healthy Men
Not Applicable
Completed
- Conditions
- Glucose Metabolism
- Interventions
- Dietary Supplement: L-arabinose - effect on glucose metabolism
- Registration Number
- NCT01801540
- Lead Sponsor
- University of Copenhagen
- Brief Summary
The purpose of this study is to investigate the effect of a meal containing different doses of L-arabinose, on the intestinal sucrase activity after intake We measure this by measuring the glucose, insulin and c-peptide after meals. Other measurements are made (glucagon and GLP-1) to explain the correlations.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 17
Inclusion Criteria
- Healthy male
- normal weight (BMI 18,5-25 kg/m2)
- 18-30 years of age
Exclusion Criteria
- Not healthy,including those with diabetes Mellitus, high bloodpressure, dyslipidemia or a infectious diseases (hepatitis or HIV), gastrointestinal disorders
- Central adipositas (defined as waist circumference > 94 cm for european men)
- Daily intake of vitamins and minerals, 3 months before the trail starts and during the trail.
- elevated alcoholcunsumption(> 21 units af alcohol pr. week)
- take medicine
- Elite athlete with intensive training
- given bloddonation within the last 3 months
- smoking
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 5 % arabinose meal sucrose/starch L-arabinose - effect on glucose metabolism A meal containing a bon with butter and marmalade, a cup cake, The and water 10 % arabinose meal sucrose/starch L-arabinose - effect on glucose metabolism A meal containing a bon with butter and marmalade, a cup cake, The and water 0 % arabinose meal Starch L-arabinose - effect on glucose metabolism A meal containing two bons with butter and cheese, The and water 0% arabinose meal sucrose/starch L-arabinose - effect on glucose metabolism A meal containing a bon with butter and marmalade, a cup cake, The and water 5 % arabinose meal starch L-arabinose - effect on glucose metabolism A meal containing two bons with butter and cheese, The and water 10 % arabinose meal starch L-arabinose - effect on glucose metabolism A meal containing two bons with butter and cheese, The and water
- Primary Outcome Measures
Name Time Method Glucose -15, 0, 15, 30, 45, 60, 90, 120, 180 min Level of glucose over time, The AUC, the peak value and time to peak
Insulin -15, 0, 15, 30, 45, 60, 90, 120, 180 min Level of insulin over time, the AUC, the peak value and time to peak
C-peptide -15, 0, 15, 30, 45, 60, 90, 120, 180 min Level of c-peptide over time, The AUC, the peak value and time to peak
- Secondary Outcome Measures
Name Time Method Glucagon -15, 0, 15, 30, 45, 60, 90, 120, 180 min Level of glucagon over time, The AUC, the peak value and time to peak
GLP-1 -15, 0, 15, 30, 45, 60, 90, 120, 180 min Level of GLP-1 over time, The AUC, the peak value and time to peak