The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man
- Conditions
- Insulin Resistance
- Registration Number
- NCT01957098
- Lead Sponsor
- University of Copenhagen
- Brief Summary
The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.
- Detailed Description
Based on previous scientific results we hypotesize, that pentoses decreases the demand for insulin in metabolizing a given dose of sucrose.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 14
- healthy males
- BMI between 18.4-25 kg/m2
- age between 18 and 30
- donation of blood 3 months before or during the study
- gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease (HIV or hepatitis)
- smoking
- consumption of more than 21 alcoholic drinks/week
- elite athletes
- on medication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Blood glucose, insulin, C-peptide and GLP-1 -15, 0, 15, 30, 45, 60, 90, 120, 180 min Level of glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) over time, the area under the curve (AUC), the peak value and time to peak
- Secondary Outcome Measures
Name Time Method Appetite measurements and energy intake -15, 30, 60, 90, 120, 150 and 180 min Appetite measurements: area under/over the curve (AUC/AOC), 3-h mean. Energy intake: the ad libitum energy intake at lunch was registered. VAS was used to asses the palatability (appearance, smell, taste, after-taste and overall palatability) of the ad libitum lunch.
Trial Locations
- Locations (1)
Institute of Human Nutrition, The Royal Veterinary and Agricultural University
🇩🇰Frederiksberg, Denmark