The effect of L-arabinose on glycaemic and insulinemic response in a liquid and a solid product.

Completed

• Conditions: 10018424; Diabetes type 2; metabolic diseases

• Registration Number: NL-OMON43485
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 18

Inclusion Criteria

• 18-35 Years old while signing the informed consent
• Good Dutch speaking, writing, understanding
• Healthy: as judged by the subject
• Stable body weight, i.e. no reported weight loss or weight gain of > 5 kg in the two months prior to the screening session
• Normal fasting glucose concentration <6.1 mmol/L, measured by finger prick
• Normal hemoglobine (Hb) concentration >8.5 mmol/L for men and >7.5 mmol/L for females, measured by finger prick

Exclusion Criteria

• Women being pregnant or lactating
• Allergy, intolerance or oversensitivity for food products
• Having a history of medical or surgical events that may affect the study outcome
• Having reported gastro-intestinal problems
• Medical drug use that may affect the study outcome
• Current antibiotics usage or in the two months prior to the screening session
• Not willing to eat or drink the test products
• Use of dietary supplements that may affect the study outcome
• Currently using a slimming or medically prescribed diet or having used one in the two months prior to the screening session
• Excessive alcohol consumption (>21 glasses/week on average)
• Planning to change physical activity pattern during the study period
• Having blood vessels that are too difficult for inserting a cannula, as judged by the study nurse
• Recent blood donation (<1 month prior to Day 1 of the study)
• Planning to donate blood as a blood donor during the study
• Not having a general practitioner
• Being an employee or a student doing a thesis or internship at the department of Human Nutrition
• Current participation in other research

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Glycaemic response, measured as iAUC, peak and time-to-peak of blood glucose<br /><br>during 180 minutes;<br /><br>2) Insulinemic response, measured as AUC, peak and time-to-peak of plasma<br /><br>insulin during 180 minutes; </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>3) L-arabinose in plasma;<br /><br>4) GLP-1 in plasma;<br /><br>5) Subsequent ad libitum food intake, measured as total energy and<br /><br>macronutrient intake;<br /><br>6) Appetite feelings, measured by a VAS-questionnaire at multiple time points<br /><br>during 180 minutes;<br /><br>7) Gastro-intestinal comfort using a questionnaire;<br /><br>8) Study diary;<br /><br>9) L-arabinose in urine.</p><br>