The effect of arabinose on sucrose-induced glycemic response and glycemic kinetics as measured by a dual stable isotope methodology

Completed

• Conditions: This study will evaluate the glycemic response to sucrose with the addition of L-arabinose; high blood glucose; Hyperglycemia

• Registration Number: NL-OMON45763
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 13

Inclusion Criteria

- Male/Female
- Aged 18-35 y
- BMI 18.5 - 25.0 kg/m2
- Healthy
- Recreationally active (participating in recreational sports activities <= 3 times per week)

Exclusion Criteria

- Smoking
- Food allergies
- Diagnosed diabetes (type 1 or type 2); fasting glucose >=7.0 mmol/l and/or glucose >=11.1 mmol/l after 2 h OGTT
- Diagnosed metabolic or gastrointestinal disorders
- Previous participation in a 13C-glucose or 2H-glucose tracer study within the last two weeks
- Unstable weight over the last three months
- Blood donation in the past two months
- Use of medication
- High alcohol consumption (>2 drinks per day; >7 drinks per week)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Total rate of glucose appearance (RaT), exogenous rate of glucose appearance<br /><br>(RaE), total rate of glucose disappearance (RdT) and exogenous rate of glucose<br /><br>disappearance (RdE) from percentage of [6,6-2H2]-glucose and of ingested<br /><br>13C-glucose from sucrose-(glucose-13C6) in plasma glucose; plasma glucose and<br /><br>insulin concentrations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma FFA and glycerol, whole-body carbohydrate and fat oxidation rates using<br /><br>indirect calorimetry.</p><br>