The effect of arabinose on sucrose hydrolysis by sucrase and glucose absorption and glycaemic response
- Conditions
- obesitasdiabetesmetabolic diseases
- Registration Number
- NL-OMON42017
- Lead Sponsor
- Cosun Biobased Products
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 18
• Male
• 18-35 Years old while signing the informed consent
• Good Dutch speaking, writing, understanding
• Healthy: as judged by the subject
• BMI: 18.5-25 kg/m2
• Stable body weight, i.e. no reported weight loss or weight gain of > 5 kg in the two months prior to the screening session
• Normal fasting glucose concentration <6.1 mmol/L
• Normal Hb concentration >8.5 mmol/L
• Allergy, intolerance or oversensitivity for the food products under study
• Having a history of medical or surgical events that may affect the study outcome
• Having reported gastro-intestinal problems
• Medical drug use that may affect the study outcome
• Current antibiotics usage or in the two months prior to the screening session
• Not willing to eat muffins or to drink fruit-based drinks
• Being a vegetarian (not willing to eat meat)
• Use of dietary supplements that may affect the study outcome
• Currently using a slimming or medically prescribed diet or having used one in the two months prior to the screening session
• Excessive alcohol consumption (>21 glasses/week on average)
• Mental status that is incompatible with the proper conduct of the study
• Elite athletes, i.e. exercise > 7h/week vigorously
• Planning to change physical activity pattern during the study period
• Having blood vessels that are too difficult for inserting a cannula, as judged by the study nurse
• Recent blood donation (<1 month prior to Day 01 of the study)
• Willing to donate blood during the study
• Not having a general practitioner
• Being an employee of Wageningen University, department of Human Nutrition
• Current participation in other research
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The glycaemic response, measured as AUC of plasma glucose during 180 minutes.</p><br>
- Secondary Outcome Measures
Name Time Method <p>1) The insulin response, measured as AUC of plasma insulin during 180 minutes.<br /><br>2) The recovery of stable isotope in breath as a marker for sucrose<br /><br>metabolisation during 180 minutes.<br /><br>3) Ad libitum energy intake, measured as lunch after 240 minutes.<br /><br>4) Appetite, measured using a VAS-questionnaire during 300 minutes.<br /><br>5) Gastro-intestinal comfort using a questionnaire.<br /><br>6) Study diary.</p><br>