Fibrinogen gamma and response to thrombolytic therapy in acute ischemic stroke

• Conditions: ischemic stroke; stroke; 10007963

• Registration Number: NL-OMON34726
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

-a clinical diagnosis of acute ischaemic stroke
- a measurable deficit on the NIHSS or NIHSS supplemental motor score
- treatment with intravenous or intra-arterial alteplase

Exclusion Criteria

contra-indications for treatment with iv or ia rt-PA, i.e.
-cerebral infarction within the previous 6 weeks,
-a history of intracerebral hemorrhage,
-severe head injury the previous 4 weeks,
-major surgery, gastrointestinal bleeding or urinary tract bleeding within the previous 2 weeks
-arterial blood pressure > 185/110 mmHg,
-blood glucose < 2.7 or > 22.2 mmol/l,
-clinical signs of hemorrhagic diathesis or platelet count <90 x 10*9/L, APTT>50 sec or INR >1.7.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Neurological improvement by means of the NIHSS at 24 hours and discharge. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The extent of fibrinogen breakdown measured by markers of fibrinolysis (such as<br /><br>plasma D-dimer concentrations).</p><br>