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Clinical Trials/NCT01483807
NCT01483807
Completed
N/A

Treatments of Acquired Apraxia of Speech

VA Office of Research and Development1 site in 1 country20 target enrollmentAugust 1, 2011

Overview

Phase
N/A
Intervention
Not specified
Conditions
Aphasia
Sponsor
VA Office of Research and Development
Enrollment
20
Locations
1
Primary Endpoint
Speech Production: Effect Size for Treated Items
Status
Completed
Last Updated
7 years ago

Overview

Brief Summary

This study was designed to examine the effects of speech therapy on ability to produce speech sounds in persons with acquired apraxia of speech.

Detailed Description

This study was designed to investigate the effects of Sound Production Treatment (SPT; a treatment for acquired apraxia of speech) on sound production accuracy in persons with chronic apraxia of speech (AOS). Organization of practice (blocked practice or randomized practice) will be manipulated in an effort to determine the most efficacious application of SPT. A combination of group and single-subject experimental designs wasl be completed with 20 speakers with AOS (2 groups of 10 participants).

Registry
clinicaltrials.gov
Start Date
August 1, 2011
End Date
December 31, 2017
Last Updated
7 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Must have acquired apraxia of speech that occurred following a stroke or other brain injury.
  • Must be at least 6 months post-onset of brain injury.
  • May have aphasia.

Exclusion Criteria

  • History of drug or alcohol abuse.
  • History of mental illness.
  • Neurological condition other than that which resulted in apraxia of speech.

Outcomes

Primary Outcomes

Speech Production: Effect Size for Treated Items

Time Frame: Pre treatment (2-3 week period preceding the start of treatment) vs. 10 weeks post all treatment

Change in accuracy of articulation of trained items as measured from baseline to 10 weeks post treatment using effect size calculations as the indicator of magnitude of change; production of words designated for treatment was measured repeatedly in non treatment probes prior to treatment, throughout all study phases, and at 10 weeks post treatment with percent accuracy calculated for each probe (maximum = 100%, minimum = 0% correct). Effect size calculations involved calculating the difference between post- and pre-treatment probe accuracy percentages with corrections made for variability (standard deviations in performance). The larger the effect size, the greater the change in performance from pre-treatment. Positive effect sizes = increases in accuracy \& negative effect sizes = decreases in accuracy.

Speech Production: Percent Change in Treated Items

Time Frame: baseline to 10 weeks post treatment

Change in accuracy of articulation of treated items as measured by percent increase in accuracy above the highest baseline measurement; production of words designated for treatment was measured repeatedly in non treatment probes prior to treatment, throughout all study phases, and at 10 weeks post treatment with percent accuracy calculated for each probe (0% to 100% correct). The highest percentage accuracy achieved in pre-treatment probes was subtracted from the percentage accuracy achieved at 10 weeks post-treatment to obtain change in accuracy value - this reflects change from maximum correct performance in baseline (pre-treatment). e.g., if in baseline probes, performance ranged from 10% to 30% accuracy and at post treatment performance was 90% accuracy, the change value would be 60% (90% minus 30%). A greater change value indicates greater change in articulation/production of words. Change could be positive (improved articulation) or negative (poorer articulation).

Secondary Outcomes

  • Speech Production of Untrained Items: Effect Sizes for Untrained Items(Baseline vs. 10 weeks post all treatment)
  • Speech Production: Percent Change in Untrained Items(baseline to 10 weeks post treatment)

Study Sites (1)

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