Analysis of the Prognostic Correlation Between Body Composition Analysis and Fatty Liver Progression in Patients With Fatty Liver Using Low-dose CT
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- relationship between body composition analysis result from CT and liver fat fraction
研究概览
简要总结
This study investigates relationship between fatty liver prognosis and body composition analysis result based on non-contrast low dose CT in patients with fatty liver disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •metabolic dysfunction-associated fatty liver disease (fatty liver with overweight/obesity, or type II DM or other metabolic dysfunction)
- •or non-alcoholic fatty liver disease with liver function test abnormality
- •signed informed consent
排除标准
- •chronic hepatitis B or C
- •other disease related to fatty liver such as glycogen storage disease, lipodystrophy, familial combined hyperlipidemia, hypobetalipoproteinemia, Weber-Christian syndrome or abetalipoproteinemia
- •on medication related to hepatic steatosis (tamoxifen, steroid, valproic acid, methotrexate, amiodarone)
- •diabetes after pancreatectomy
- •history of total parenteral nutrition in 6 months
- •pregnancy or nursing mother
研究组 & 干预措施
non-contrast low-dose abdomen CT
non-contrast low-dose abdomen CT (target effective dose: < 1.5 mSv). CT based body composition analysis is performedd with commercially available automatic segmentation software (DeepCatch, Medical IP, South Korea).
干预措施: Non-contrast low-dose abdomen CT (Diagnostic Test)
non-contrast low-dose abdomen CT
non-contrast low-dose abdomen CT (target effective dose: < 1.5 mSv). CT based body composition analysis is performedd with commercially available automatic segmentation software (DeepCatch, Medical IP, South Korea).
干预措施: Fibroscan (Diagnostic Test)
non-contrast low-dose abdomen CT
non-contrast low-dose abdomen CT (target effective dose: < 1.5 mSv). CT based body composition analysis is performedd with commercially available automatic segmentation software (DeepCatch, Medical IP, South Korea).
干预措施: bioelectrical impedance analysis (BIA) (Diagnostic Test)
结局指标
主要结局
relationship between body composition analysis result from CT and liver fat fraction
时间窗: 6 month after CT acquisition
relationship between visceral fat volume fraction (obtained from CT analysis using automatic body segmentation, unitless (visceral fat fraction = visceral fat volume/total body volume)) and CAP value of fibroscan
次要结局
- ratio of appropriate non-contrast low dose abdomen CT acquisition & analysis(6 month after CT acquisition)
- relationship between body composition analysis result from CT and hepatic fibrosis(6 month after CT acquisition)
- agreement between body composition analysis result from CT and bioelectrical impedance analysis (Inbody test)(6 month after CT acquisition)
研究者
Jeong Min Lee
Professor
Seoul National University Hospital