Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Short- and Long-term Outcomes in Patients with Gastric Cancer
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 4,000
- 试验地点
- 3
- 主要终点
- Overall survival
研究概览
简要总结
This study aims to create a clinical prediction model. Abdominal fat and muscle area also play an important role in the prediction of surgical outcomes in colorectal cancer. Studies have shown that excess visceral fat and low skeletal muscle mass (sarcopenia) are associated with poorer postoperative outcomes, including a higher risk of postoperative complications and lower survival. Preoperative imaging techniques such as CT, MRI and ultrasound that provide accurate measurements to assess abdominal fat and muscle area can help surgeons develop individualized surgical and rehabilitation plans, improve surgical success, reduce complications and improve long-term patient prognosis. In this study, the investigators expected to construct a prediction model of abdominal fat and muscle area on the short- and long-term outcomes of gastric and colorectal cancer patients by calculating the abdominal fat and muscle area in different levels of abdominal CT images, in order to further adjust and guide the treatment plan.
详细描述
This is a retrospective observational study, which is expected to include patients diagnosed with gastric cancer and undergoing radical gastric cancer surgery in the Department of Gastrointestinal Surgery of the First Affiliated Hospital of Chongqing Medical University, the Department of Gastrointestinal Surgery of the Second Affiliated Hospital of Chongqing Medical University, the Department of Gastrointestinal Surgery of the Affiliated Yongchuan Hospital of Chongqing Medical University, and the Department of Gastrointestinal Surgery of the Qijiang People's Hospital, and to discuss the predictive effects of abdominal fat and muscle area on the short-term and long-term outcomes of gastric cancer patients after surgery.
- Case collection Patients diagnosed with gastric cancer and undergoing radical gastric cancer surgery were screened according to the inclusion criteria. All patients had signed informed consent.
Inclusion criteria:
-
Diagnosed with gastric cancer by pathology or cytology;
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Age >18 years;
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Not having received chemotherapy, radiotherapy, targeted therapy or immunotherapy;
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Patients with postoperative pathological stages other than stage IV, or without metastases in liver, lung or other distant organs confirmed by CT, MRI or B-ultrasound imaging and without surgical treatment;
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Pre-operative CT examination data were kept in our hospital.
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Data collection Collect patients' preoperative baseline information such as gender, age, body mass index (BMI), complications, tumor stage, etc. Collect patients' preoperative CT scans (make sure to include images from lumbar 1 to lumbar 5). Collect patients' surgical conditions such as operation time and intraoperative bleeding. Collect patients' postoperative complications during hospitalization; 3. Prognostic follow-up Closely follow up the death or cancer recurrence of patients after surgery. 4. Outcome indicators
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of gastric cancer or colorectal cancer confirmed by pathology or cytology;
- •aged >18 years;
- •not received chemotherapy, radiotherapy, targeted therapy or immunotherapy;
- •post-operative pathological stages other than stage IV, or no liver, lung or other organs as confirmed by CT, MRI, B-ultrasound imaging.
- •patients who have pre-operative CT examination data kept in our hospital.
排除标准
- •Poor quality of preoperative CT images;
- •refusal to participate in this study.
结局指标
主要结局
Overall survival
时间窗: From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months
Overall survival was defined as time from date of diagnosis until the date of death from any cause or or loss to follow-up.
次要结局
- Rate of postoperative complications(From date of surgery until the date of first documented postoperative complication, assessed up to 2 months after surgery.)
研究者
Dong Peng
Dr.
First Affiliated Hospital of Chongqing Medical University