跳至主要内容
临床试验/NCT03482921
NCT03482921已完成不适用

Body Parameters as an Independent Predictor of Acute Pancreatitis: A Propensity Score-matched Case-control Study

Ningbo No. 1 Hospital1 个研究点 分布在 1 个国家目标入组 1,662 人开始时间: 2017年12月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
1,662
试验地点
1
主要终点
Comparisons of variables according to AP severity

研究概览

简要总结

This study is to assess the predictive significance of visceral adipose tissue (VAT) and visceral adipose tissue /skeletal muscle tissue ratio (VAT/SMT ratio) for the prognosis in acute pancreatitis (AP) patients.

详细描述

Acute pancreatitis (AP) is a sudden inflammation of the pancreas. However, one-fifth of patients may develop severe complications with a mortality between 10%-20% It remains a difficulty to find an effective method for prediction of severity of AP at early stage.

It is well-established that obesity (defined as body mass index[BMI]>30kg/m2 by the World Health Organization) is a risk factor for AP and increases the incidence of systemic complication, motality. There are a lot of parameters related to saropenic obesity, including areas of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), skeletal muscle tissue (SMT), and VAT/SMT ratio. it is unclear which parameter is the best predictor of severe AP. Thus, this study is aimed to investigate the association between these parameters and AP severity and find the best predictor of AP.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 100 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • diagnosed with AP
  • age >18 years

排除标准

  • age<18years
  • missing data in the electronic medical record
  • history of AP

结局指标

主要结局

Comparisons of variables according to AP severity

时间窗: the physical examination data in the year of 2017

Comparisons of variables according to AP severity by one-way analysis of variance (ANOVA) and Likelihood Ratio

Relationships between VAT and severity outcomes Relationships between VAT and severity outcomes Relationships between VAT and severity outcomes Relationships between body parameters and severity outcomes

时间窗: the physical examination data in the year of 2017

Relationships between VAT and severity outcomes by Likelihood Ratio

次要结局

未报告次要终点

研究者

发起方
Ningbo No. 1 Hospital
申办方类型
Other
责任方
Sponsor

研究点 (1)

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