Body Parameters as an Independent Predictor of Acute Pancreatitis

Completed

• Conditions: Acute Pancreatitis

• Registration Number: NCT03482921
• Lead Sponsor: Ningbo No. 1 Hospital

Brief Summary

This study is to assess the predictive significance of visceral adipose tissue (VAT) and visceral adipose tissue /skeletal muscle tissue ratio (VAT/SMT ratio) for the prognosis in acute pancreatitis (AP) patients.

Detailed Description

Acute pancreatitis (AP) is a sudden inflammation of the pancreas. However, one-fifth of patients may develop severe complications with a mortality between 10%-20% It remains a difficulty to find an effective method for prediction of severity of AP at early stage.

It is well-established that obesity (defined as body mass index\[BMI\]\>30kg/m2 by the World Health Organization) is a risk factor for AP and increases the incidence of systemic complication, motality. There are a lot of parameters related to saropenic obesity, including areas of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), skeletal muscle tissue (SMT), and VAT/SMT ratio. it is unclear which parameter is the best predictor of severe AP. Thus, this study is aimed to investigate the association between these parameters and AP severity and find the best predictor of AP.

Study Timeline

• Study Start: 2017-12-01
• Primary Completion: 2018-02-12
• Status Verified: 2018-03
• Study Completion: 2018-03-22
• Study First Submitted: 2018-03-23
• Study First Submitted QC: 2018-03-23
• Last Update Submitted: 2018-03-23
• Study First Posted: 2018-03-29
• Last Update Posted: 2018-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1662

Inclusion Criteria

1. diagnosed with AP
2. age >18 years

Exclusion Criteria

1. age<18years
2. missing data in the electronic medical record
3. history of AP

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparisons of variables according to AP severity	the physical examination data in the year of 2017	Comparisons of variables according to AP severity by one-way analysis of variance (ANOVA) and Likelihood Ratio
Relationships between VAT and severity outcomes Relationships between VAT and severity outcomes Relationships between VAT and severity outcomes Relationships between body parameters and severity outcomes	the physical examination data in the year of 2017	Relationships between VAT and severity outcomes by Likelihood Ratio

Trial Locations

Locations (1)

Ningbo NO.1 hospital; 🇨🇳 Ningbo, Zhejiang, China