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Biomarkers Derived From Adipose Tissue Useful for Diagnosis and Prognosis of Cardiovascular Risk (CVR) in Obese Patient

Conditions
Diabetes Mellitus
Inflammatory Response
Metabolic Syndrome
Registration Number
NCT03561987
Lead Sponsor
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Brief Summary

This study evaluates the relationship between the adipose tissue, as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.

Detailed Description

Bariatric surgery induces a significant reduction in co-morbidities associated with obesity, such as Diabetes mellitus, dyslipidemia, liver disease, arterial hypertension, obstructive apnea and cardiovascular risk. However this does not happen in all obese patients, even when there is a weight reduction.

It is known that the adipose tissue is actively involved in synthesis of cytokines and its role in metabolic phenotypes has been suggested. It is possible that the intrinsic mechanisms of adipose tissue participate in several benefits observed in morbidly obese patients who undergo to an anti-obesity surgery.

So this study explores the involvement of adipose tissue as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
70
Inclusion Criteria
  • Above 18 years old.
  • Morbid obese patients candidates to bariatric surgery.
Exclusion Criteria
  • Second bariatric surgery

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Evaluate the association of the cardiovascular benefit of the obese patient after bariatric surgery with the basic mechanisms of adipose tissue (metabolic profile)3 years

Evaluate the association of the cardiovascular benefit of the obese patient after bariatric surgery with the basic mechanisms of adipose tissue (metabolic profile)

Secondary Outcome Measures
NameTimeMethod
Correlation between serum concentration of pro-inflammatory biomarker and the reduction of subclinical endothelial disfunction.9 months

measurements of carotid intima-media thickness (CIMT) in millimeter and Flow mediated dilatation (FMD) in percent in a basal time and see over time the reduction (if any) of those endothelial markers

Determine the association of the cardiovascular prognosis modification (risk subgroups) with the basal metabolic profile.9 months

After the 9 months follow up, the authors will correlated the pro-inflammatory cytokines, presence or absence of adipose proteins.

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