Identification of Biomarkers Derived From Adipose Tissue With Potential Utility in the Diagnosis and Prognosis of Cardiovascular Risk of the Obese Patient.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metabolic Syndrome
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
- Enrollment
- 70
- Primary Endpoint
- Evaluate the association of the cardiovascular benefit of the obese patient after bariatric surgery with the basic mechanisms of adipose tissue (metabolic profile)
- Last Updated
- 7 years ago
Overview
Brief Summary
This study evaluates the relationship between the adipose tissue, as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.
Detailed Description
Bariatric surgery induces a significant reduction in co-morbidities associated with obesity, such as Diabetes mellitus, dyslipidemia, liver disease, arterial hypertension, obstructive apnea and cardiovascular risk. However this does not happen in all obese patients, even when there is a weight reduction. It is known that the adipose tissue is actively involved in synthesis of cytokines and its role in metabolic phenotypes has been suggested. It is possible that the intrinsic mechanisms of adipose tissue participate in several benefits observed in morbidly obese patients who undergo to an anti-obesity surgery. So this study explores the involvement of adipose tissue as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.
Investigators
Juan Antonio Suárez Cuenca
Ph.D. in Biomedical sciences
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Eligibility Criteria
Inclusion Criteria
- •Above 18 years old.
- •Morbid obese patients candidates to bariatric surgery.
Exclusion Criteria
- •Second bariatric surgery
Outcomes
Primary Outcomes
Evaluate the association of the cardiovascular benefit of the obese patient after bariatric surgery with the basic mechanisms of adipose tissue (metabolic profile)
Time Frame: 3 years
Evaluate the association of the cardiovascular benefit of the obese patient after bariatric surgery with the basic mechanisms of adipose tissue (metabolic profile)
Secondary Outcomes
- Correlation between serum concentration of pro-inflammatory biomarker and the reduction of subclinical endothelial disfunction.(9 months)
- Determine the association of the cardiovascular prognosis modification (risk subgroups) with the basal metabolic profile.(9 months)