NEFA (Non Esterified Fatty Acid) , Adipose Factors Behind Insulin Sensitivity

Not Applicable

Completed

• Conditions: Non-obese Controls; Obesity

• Registration Number: NCT01727245
• Lead Sponsor: Karolinska Institutet

Brief Summary

We want to asses the role of adipose tissue for metabolic complications to obesity before and after weight loss (surgery).

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2012-11-12
• Study First Submitted QC: 2012-11-12
• Study First Posted: 2012-11-15
• Primary Completion: 2019-12
• Study Completion: 2019-12
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-27
• Last Update Posted: 2020-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity, adipose tissue function and gene function	two years after surgery	Performed with hyperinsulinemic euglycemic clamp before and two years after surgery. Subcutaneous and visceral fat biopsy at the time of surgery.

Secondary Outcome Measures

Name	Time	Method
Body composition	two years after surgery	DEXA (Dual-Energy X-ray absorptiometry), before and two years after surgery
Vascular function	two years after surgery	Non invasive ultrasound of vascular stiffness, before and two years after surgery

Trial Locations

Locations (3)

Ersta Hospital; 🇸🇪 Stockholm, Sweden

Karolinska University Hospital; 🇸🇪 Stockholm, Sweden

Danderyds Hospital; 🇸🇪 Stockholm, Sweden