Body Composition and Fatty Liver Disease
- Conditions
- Fatty Liver
- Registration Number
- NCT05695118
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
This study investigates relationship between fatty liver prognosis and body composition analysis result based on non-contrast low dose CT in patients with fatty liver disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 150
- metabolic dysfunction-associated fatty liver disease (fatty liver with overweight/obesity, or type II DM or other metabolic dysfunction)
- or non-alcoholic fatty liver disease with liver function test abnormality
- signed informed consent
- chronic hepatitis B or C
- other disease related to fatty liver such as glycogen storage disease, lipodystrophy, familial combined hyperlipidemia, hypobetalipoproteinemia, Weber-Christian syndrome or abetalipoproteinemia
- on medication related to hepatic steatosis (tamoxifen, steroid, valproic acid, methotrexate, amiodarone)
- diabetes after pancreatectomy
- history of total parenteral nutrition in 6 months
- pregnancy or nursing mother
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method relationship between body composition analysis result from CT and liver fat fraction 6 month after CT acquisition relationship between visceral fat volume fraction (obtained from CT analysis using automatic body segmentation, unitless (visceral fat fraction = visceral fat volume/total body volume)) and CAP value of fibroscan
- Secondary Outcome Measures
Name Time Method ratio of appropriate non-contrast low dose abdomen CT acquisition & analysis 6 month after CT acquisition Number of CT scan with effective dose \< 1.5 mSv AND successful automatic body composition analysis (without manual editing) divided by total number of CT scan
relationship between body composition analysis result from CT and hepatic fibrosis 6 month after CT acquisition relationship between visceral fat volume fraction (CT analysis using automatic body segmentation, unitless (visceral fat fraction = visceral fat volume/total body volume)) and liver stiffness value of fibroscan
agreement between body composition analysis result from CT and bioelectrical impedance analysis (Inbody test) 6 month after CT acquisition agreement of visceral fat, subcutaneous fat, muscle amount between CT based body composition and Inbody test results
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital🇰🇷Seoul, Korea, Republic of