Are there differences in central nervous system processing in patients with refractory chronic cough?

Not Applicable

Completed

• Conditions: Chronic cough; Respiratory

• Registration Number: ISRCTN88737146
• Lead Sponsor: Wythenshawe Hospital Research and Development Directorate

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-12-10
• Study Completion: 2022-09-09
• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

1. Males and females 18-80 years, inclusive
2. Non-smokers >6 months; ex-smokers <20 pack years

Healthy Volunteers
3. No clinically relevant abnormalities based on the medical history, physical examination, vital signs
4. No history of current or significant past respiratory disease, specifically a diagnosis of asthma
5. Spirometry within normal limits

Chronic Cough Patients
6. Have a refractory chronic cough as defined by BTS guidelines
7. No evidence of asthma

Exclusion Criteria

1. Routine contraindications to fMRI scanning e.g. certain metal implants, recent surgery, extreme claustrophobia etc
2. Any condition that may increase airway/circulating levels of ATP/adenosine e.g. chronic cardiac failure, chronic hypoxia, vigorous exercise within 48 hours
3. Pregnant or breastfeeding
4. Upper or lower respiratory tract infection or significant change in pulmonary status within 4 weeks of enrolment
5. Any therapy that may modulate cough (e.g. ACE inhibitors, opioids, gabapentin). Patients can be included if they are willing/able to discontinue these for the study duration and a suitable washout period

Study & Design

• Study Type: Observational
• Study Design: Not specified