The Effect of Nocturnal Haemodialysis on Arterial Stiffness

Completed

• Conditions: Arterial Stiffness; End Stage Renal Disease

• Registration Number: NCT00641875
• Lead Sponsor: Melbourne Health

Brief Summary

Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12
• Primary Completion: 2008-02
• Study Completion: 2008-02
• Study First Submitted: 2008-03-17
• Study First Submitted QC: 2008-03-21
• Study First Posted: 2008-03-24
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-23
• Last Update Posted: 2015-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• adult dialysis patients
• able to perform home nocturnal haemodialysis

Exclusion Criteria

• age < 18 and > 80 years
• any patient who is anticipating a live renal transplantation in forthcoming 12 months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis.	12 months

Secondary Outcome Measures

Name	Time	Method
To examine the relationship between arterial stiffness and clinical and biochemical parameters	12 months