TO COMPARE THE EFFICACY OF INTRAVENOUS CLONIDINE , LIGNOCAINE NEBULIZATION AND A COMBINATION OF BOTH FOR ATTENUATION OF PRESSOR RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- To Evaluate The Efficacy Of Intravenous Clonidine And Lignocaine Nebulization For Attenuation Of Pressor Response To Laryngoscopy And Tracheal Intubation In Terms Of Heart Rate,Blood Pressure,Oxygen Saturation And ECG Changes
研究概览
简要总结
a placebo controlled study to compare the effect of intravenous clonidine, lignocaine nebulization and a combination of both for attenuation of pressor response to laryngoscopy and tracheal intubation in terms of heart rate, blood pressure, oxygen saturation and ECG changes. Study will be done on 75 patients posted for elective surgeries under general anaesthesia with 25 patients in each 3 groups. Group C will receive intravenous clonidine 1 mcg/kg and nebulization with 0.075 ml/kg normal saline. Group L will receive intravenous normal saline 10 cc and nebulization with 3 mcg/kg (0.075 ml/kg) of 4% lignocaine. Group CL will receive intravenous clonidine 1 mcg/kg and nebulization with 3 mcg/kg (0.075 ml/kg) of 4 % lignocaine. Study drugs will be given 15 min prior to intubation.
Intraopertaive hemodynamic parameters and complications will be noted.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grade 1 or 2 Mallampatti grade 1 or 2.
排除标准
- •Patient refusal Anticipated and unanticipated difficult airway Hypertension, ischemic heart disease,pregnancy and patients receiving antihypertensives, sympathomimetics,antidepressants and vagomimetics Known allergy to study drugs.
结局指标
主要结局
To Evaluate The Efficacy Of Intravenous Clonidine And Lignocaine Nebulization For Attenuation Of Pressor Response To Laryngoscopy And Tracheal Intubation In Terms Of Heart Rate,Blood Pressure,Oxygen Saturation And ECG Changes
时间窗: Baseline,Pre-induction,Every 1 Min For First 10 Minutes And Then Every 10 Minutes Till The End Of Surgery
次要结局
- To Study The Incidence Of Intra-operative Complications Associated With Study Drugs(Intraoperatively)