Comparison between Clonidine and Lignocaine in response to laryngoscopy and endotracheal intubation

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/10/037063
• Lead Sponsor: Dr Shahbaz Haroon

Brief Summary

It is a randomized, prospective, comparative, double blinded, observational study where in intravenous lignocaine and intravenous clonidine are compared for the attenuation of hemodynamic pressor responses during laryngoscopy and endotracheal intubation before any surgical procedures in the operation theatre.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-02-10
• Study Start: 2021-10-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Age between 18-60 yr of either sex.
• ASA grade I and grade II.
• Patients posted for elective surgeries under general anesthesia requiring intubation.
• Hemodynamically stable patients having all routine investigations within normal limits.
• Patients who give written informed consent and are willing to be part of the study.

Exclusion Criteria

• Patients refusal.
• Patients with ASA physical status III and more.
• Patients with any pre-existing cardiovascular disease.
• Patients with h/o allergy to test drugs.
• Patients posted for emergency surgeries.
• Patients with difficult airway.
• Patients with neurological disorders and muscle diseases.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To observe the attenuation of pressor responses to laryngoscopy and endotracheal intubation with intravenous clonidine	PRE INTUBATION, SCOPY 0 MINS, EVERY 5 MINUTES, UPTO 2 HOURS INTRA-OP, POST OP VAS, SEDATION

Secondary Outcome Measures

Name	Time	Method
To study the side effects of Clonidine and Lignocaine, if any and Ramsay sedation scale	Ramsay sedation scale: immediately, 1 hour, 6 hour and 12 hour after surgery

Trial Locations

Locations (1)

Hightech OT complex, 5th floor, Hightech building; 🇮🇳 Pune, MAHARASHTRA, India

Hightech OT complex, 5th floor, Hightech building

🇮🇳Pune, MAHARASHTRA, India

Dr Shahbaz Haroon

Principal investigator

8105236310

shahbaz.haroon92@gmail.com