NCT06011824已完成不适用
Megakaryocytes and Platelets, Harmful or Helpful in Breast Cancer Cell Metastasis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Platelet Counts
研究概览
简要总结
Determining if Megakaryocytes and Platelets are Harmful or Helpful in Breast Cancer Cell Metastasis
详细描述
The purpose of this study is to determine how megakaryocytes (cells in the bone marrow responsible for making platelets, which are necessary for blood clotting) affect the survival and growth/division patterns of breast cancer stem cells, and the effects of breast cancer cells on megakaryocyte survival and function. Through chart review, the study team will look at the relationship between different blood components and different breast cancer diagnoses.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Cohort 1-Biopsy negative
- •Females age 18 and above
- •Cohort 2-Biopsy positive for carcinoma in situ (ductal, lobular, or other)
- •Females age 18 and above
- •Any subtype of breast cancer
- •Cohort 3-Biopsy positive for Stage 1, 2, or 3 invasive carcinoma (ductal, lobular, or other)
- •Females age 18 and above
- •Any subtype of breast cancer
- •Have no distant metastases
- •Cohort 4-Stage 4 Metastatic Disease
- •Females age 18 and above
- •Any subtype of breast cancer
排除标准
- •Previous diagnosis with a known platelet disorder such as: Bernard Soulier disease, Jacobsen syndrome, Lowe syndrome, Thrombocytopenia, Thrombotic thrombocytopenic pupura, Von Willebrand disease, or the equivalent. Any condition in which antiplatelet or anticoagulant therapy with one of the following medications is being prescribed: Clopidogrel (Plavix), Warfarin (Coumadin or Jantoven), Prasugrel (Effient), or Ticagrelor (Brilinta).
- •Cohort 1-Biopsy negative
- •Females less than age 18
- •Cohort 2-Biopsy positive for carcinoma in situ (ductal, lobular, or other)
- •Females less than age 18
- •Currently undergoing neoadjuvant therapy
- •Cohort 3-Biopsy positive for Stage 1, 2, or 3 invasive carcinoma (ductal, lobular, or other)
- •Females less than age 18
- •Presence of distant metastases
- •Currently undergoing neoadjuvant therapy
- •Cohort 4-Stage 4 Metastatic Disease
- •Females less than age 18
- •Currently undergoing neoadjuvant therapy
- •Less than 30 days from last adjuvant treatment for Stage I-III Breast Cancer (may be on Trastuzumab, Pertuzumab, or endocrine therapy only for maintenance therapy from their prior breast cancer diagnosis)
结局指标
主要结局
Platelet Counts
时间窗: Baseline
Measure of the number of platelets in the blood, reported as platelets per microliter of blood.
次要结局
- Mean Corpuscular Volume (MCV)(Baseline)
- Lymphocyte to neutrophil ratio(Baseline)
- Levels of tumor educated platelets(Baseline)
研究者
研究点 (1)
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