Cardio- and Reno-protective Effect of Remote Ischemic Preconditioning in Patients Undergoing Percutaneous Coronary Intervention. A Prospective, Non-randomized Controlled Trial.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Assiut University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Incidence of PCI- related myocardial infarction (MI 4a) at 24 hours after PCI.
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Myocyte necrosis occurs frequently in elective percutanious percutaneous coronary intervention (PCI) and is associated with subsequent cardiovascular events. This study assessed the cardio- and reno-protective effect of remote ischemic preconditioning (RIPC) in patients undergoing elective PCI. 200 patients were randomized into 2 groups: 100 patients received RIPC (created by three 5-minute inflations of a blood pressure cuff to 200 mm Hg around the upper arm, separated by 5-minute intervals of reperfusion) < 2 hours before the PCI procedure, and the control group (n = 100).
Investigators
Ayman Khairy Mohamed Hassan
Dr.
Assiut University
Eligibility Criteria
Inclusion Criteria
- •Patients between 18 and 85 years of age,
- •scheduled to undergo an elective PCI and
- •able to give an informed consent were eligible for enrollment in the study.
- •Elective PCI was defined as any coronary revascularization in a low-risk patient who presents to the facility for a planned PCI or for a coronary angiogram followed by ad hoc PCI.
Exclusion Criteria
- •(1) emergency PCI, (2) baseline troponin value ≥ 0.04 ng/mL, (3) nicorandil or glibenclamide use (preconditioning-mimetic and preconditioning-blocking medication, respectively), (4) those who could not give informed consent, and (5) patients with severe renal impairment or on regular dialysis.
Outcomes
Primary Outcomes
Incidence of PCI- related myocardial infarction (MI 4a) at 24 hours after PCI.
Time Frame: 24 hours
PCI-related myocardial infarction (MI 4a) was defined as cardiac Troponin I (cTnI) elevation \>0.20ng/mL (5 times the upper reference limit) 24 hr. post PCI.
Secondary Outcomes
- incidence of contrast induced nephropathy (CIN) at 72 hours after contrast exposure(72 hours)