Effect of One Cycle Remote Ischemic Preconditioning on Myocardial Injury After Percutaneous Coronary Interventions in Patients With Stable Coronary Artery Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocardial Ischemia
- Sponsor
- Trakya University
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- hs-Troponin elevation
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Myocardial injury occurs after percutaneous coronary intervention due to micro emboli, ischemia-reperfusion injury or side branch occlusion. 3 cycles of ischemic preconditioning has been shown to be useful in preventing myocardial injury but it is not suitable to perform it especially in ad hoc interventions. In this study the investigators aim is to show whether one cycle remote ischemic preconditioning will be enough to prevent myocardial injury during percutaneous coronary intervention.
Detailed Description
About in one third of elective percutaneous coronary interventions (PCI) troponin release occurs showing myocardial necrosis. And it has been shown that myocardial necrosis due to coronary interventions has also adverse effects on long term prognosis. Beneficial effects of of ischemic preconditioning in elective PCI and in coronary artery bypass surgery has been shown in several studies. In most of the trials 3 cycles of ischemia was performed, but this is time consuming and it's not suitable to apply it, in ad-hoc interventions. The investigators found one study showing that one cycle will also be enough to prevent troponin elevation after elective PCI. The investigators aim was also to show that one cycle preconditioning performed just before coronary intervention will also be useful in preventing myocardial necrosis due to elective PCI.
Investigators
Mustafa Adem YILMAZTEPE
Assistant Professor Of Medicine
Trakya University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Acute or chronic renal failure (Creatinin clearance \<60ml/dk)
- •Acute heart failure
- •Presence of hemodynamic instability
- •Left main interventions
- •Acute Coronary Syndrome
- •Patients in whom cuff inflation is contraindicated in upper extremities (fistula, lymphoedema etc)
- •Patients using nicorandil, glibenclamide or trimetazidine
- •Patients not accepting the study
- •Presence of troponin elevation before intervention
- •Presence or suspicion of pregnancy
Outcomes
Primary Outcomes
hs-Troponin elevation
Time Frame: after 16 hours