Comparison Sugammadex With Neostigmine in Laryngeal Microsurgery.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- Laryngoscopic Score
Study Overview
Brief Summary
This study aims to make a comparison of surgical condition and recovery time between rocuronium 0.45 mg/kg and neostigmine group and rocuronium 0.9 mg/kg and sugammadex group.
Detailed Description
This study aims to make a comparison of surgical condition and recovery time between moderate neuromuscular bloackade with reversal using neostigmine group and deep neuromuscular bloackade with reversal using sugammadex group.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 19 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •American Society of Anesthesiologist Physical status classification 1 or 2 elective laryngeal microsurgery under general anesthesia
Exclusion Criteria
- •BMI >25 or < 20 kg/m2 Patients taking intercurrent medication Glutamic Oxalacetate Transaminase or Glutamic Pyruvate Transaminase > 40 IU/L, Cr > 1.4 mg/dl
Arms & Interventions
rocuronium 0.45 - neostigmine
when anesthetic induction, inrocuronium 0.45 mg/kg will be administered for muscle relaxation.
When the end of operation, a injection of neostigmine or sugammadex will be administered.
Intervention: Injection of neostigmine or sugammadex (Other)
rocuronium 0.9 - sugammadex
When anesthetic induction, rocuronium 0.9 mg/kg will be injected to rocuronium 0.9 - sugammadex group for muscle relaxation.
When the end of operation,, a injection of neostigmine or sugammadex be administered.
Intervention: Injection of neostigmine or sugammadex (Other)
Outcomes
Primary Outcomes
Laryngoscopic Score
Time Frame: At the beginning of surgery, the surgeon rated the laryngoscopy condition
Definitions for evaluation of Laryngoscopycondition. : Easy = jaw relaxed, no resistance to blade insertion, fair = jaw not fully relaxed, slight resistance to blade insertion, difficult = poor jaw relaxation, active resistance of the patient to laryngoscopy. Variables Excellent Good Poor
Secondary Outcomes
- Recovery Time From Neuromuscular Blockade(from the injection of neostigmine or sugammadex up to 30 minutes)