Effect Mechanism of a Non-invasive Stimulation Device for Rapid Alleviation of Parkinson's Disease Symptoms
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- Inventram
- Enrollment
- 11
- Locations
- 1
- Primary Endpoint
- fMRI - STN, PPN and cortical connectivity alterations
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Effect Mechanism Investigation of a Wearable Electrostimulator for Rapid Alleviation of Parkinson's Disease Symptoms
Detailed Description
Activation levels of interested regions of the brain will be measured through fMRI technique prior and after the dry needling and active stimulation applications.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of Parkinson's Disease
- •H\&Y Stage \>= 2
- •Existing bradykinesia symptoms
- •Existence of one of the symptoms below
- •Resting Tremor
- •Walking disorder
Exclusion Criteria
- •Cardiac Pacemaker
- •Psychiatric diagnosis
- •Irregular heart/respiration rate
- •Pregnancy
- •Alcohol consumption
- •Cardiovascular disease history
- •Wearing an electro-active prosthesis
- •Brain surgery history
- •Ongoing TENS/PENS therapy-
Outcomes
Primary Outcomes
fMRI - STN, PPN and cortical connectivity alterations
Time Frame: Baseline and PostStim (right after the stimulation is terminated)
fMRI - Activation level comparison of the motor and supplementary cortex
Time Frame: Baseline and PostStim (right after the stimulation is terminated)
fMRI - Activation level comparison of the subthalamic nucleus (STN) and basal ganglia including pedunculopontine nucleus (PPN)
Time Frame: Baseline and PostStim (right after the stimulation is terminated)