The Effect of Embryo Culture Under Low Oxygen Tension on Pregnancy Rates

Not Applicable

Completed

• Conditions: Low Oxygen Tension

• Registration Number: NCT01532193
• Lead Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA

Brief Summary

This study will determine whether the use of low oxygen tension during "in vitro" embryo culture may increase the pregnancy rates in women undergoing egg donation.

Detailed Description

As far as oxygen (O2) tension is concerned, both oocytes and embryos from different mammalian species included the human are normally surrounded by values which are much less than half of atmospheric O2, ranging from high (8.7% O2) in the rabbit oviduct, rabbit and hamster uterus, to as low as 11 mm Hg (1.5% O2) in the monkey uterus. Even in the preovulatory follicle, oocytes are bathed within follicular fluids containing oxygen that range from \> 1 to 5.5 % The aim of this study was to evaluate the impact the effect of low oxygen tension after day-3 embryo transfer in our egg donation programme on pregnancy and implantation rates.

Study Timeline

• Study Start: 2009-11
• Study First Submitted: 2012-02-09
• Study First Submitted QC: 2012-02-13
• Study First Posted: 2012-02-14
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-25
• Last Update Posted: 2015-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 380

Inclusion Criteria

• Women aged 25-45 years of age;
• In good mental and physical health;
• First or second of egg-recipient treatment;
• Embryo transfer on Day 3.
• One to three embryos will be transferred.
• BMI between 18-25 kg/m2.

Exclusion Criteria

• Uterine pathology or hydrosalpinx
• Recurrent miscarriage
• No chronic illnesses

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Clinical pregnancy rates per cycle	one month

Trial Locations

Locations (1)

Ivi Valencia; 🇪🇸 Valencia, Spain