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Clinical Trials/NCT04157660
NCT04157660
Completed
Not Applicable

Effect of Short-term Ambulatory Oxygen Therapy on Cardiopulmonary Exercise Capacity (CPET) in Patients With Heart Failure With Preserved Ejection Fraction (HFpEF)

University of Zurich1 site in 1 country10 target enrollmentSeptember 12, 2019
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ConditionsHeart Failure, Diastolic (HFpEF)

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Heart Failure, Diastolic (HFpEF)
Sponsor
University of Zurich
Enrollment
10
Locations
1
Primary Endpoint
Work Rate (Watt)
Status
Completed
Last Updated
5 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with heart failure with preserved ejection fraction.

Registry
clinicaltrials.gov
Start Date
September 12, 2019
End Date
December 31, 2020
Last Updated
5 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •HFpEF, stable medication for at least 4 weeks.

Exclusion Criteria

  • •instable status, pregnancy, clinically relevant concomitant diseases, inability to follow the study procedures

Outcomes

Primary Outcomes

Work Rate (Watt)

Time Frame: 1 day

Maximal Work Rate (Watt max) measured during cardiopulmonary exercise test oxygen vs. room air

Endurance Time (s)

Time Frame: 1 day

Endurance (s) with 75% Wmax measured during cardiopulmonary exercise test oxygen vs. room air

Secondary Outcomes

  • Changes in arterial blood parameters (pH)(1 day)
  • Changes in arterial blood parameters (PaO2)(1 day)
  • Respiratory Exchange Ratio (RER)(1 day)
  • Changes in arterial blood parameters (PaCO2)(1 day)
  • Peak Oxygen uptake (VO2 max)(1 day)
  • Changes in arterial blood parameters (Lactat)(1 day)
  • muscle tissue oxygen(1 day)
  • cerebral tissue oxygen(1 day)
  • Changes in arterial blood parameters (Bicarbonate)(1 day)

Study Sites (1)

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