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Clinical Trials/NCT03196089
NCT03196089
Completed
Phase 2

Effect of Short-term Oxygen Therapy on Cardiopulmonary Exercise (CPET) Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD)

University of Zurich1 site in 1 country20 target enrollmentJune 2, 2017
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ConditionsChronic Obstructive Pulmonary Disease

Overview

Phase
Phase 2
Intervention
Not specified
Conditions
Chronic Obstructive Pulmonary Disease
Sponsor
University of Zurich
Enrollment
20
Locations
1
Primary Endpoint
Watt
Status
Completed
Last Updated
6 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic obstructive pulmonary disease.

Registry
clinicaltrials.gov
Start Date
June 2, 2017
End Date
December 31, 2018
Last Updated
6 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •diagnosis of chronic obstructive pulmonary disease
  • •on optimized medical therapy and in stable condition for at least 4 week
  • •desaturate in the 6 minute walking test by at least 4% to values \<92%

Exclusion Criteria

  • •unstable conditions
  • •pregnant women
  • •patients with relevant concomitant lung disease and severe daytime hypoxemia

Outcomes

Primary Outcomes

Watt

Time Frame: 1 day

Exercise time

Time Frame: 1 day

Secondary Outcomes

  • Ventilatory equivalent of carbon dioxide (VE/VCO2) slope(1 day)
  • Peak Oxygen uptake(1 day)
  • Respiratory Exchange ratio(1 day)
  • End-tidal pressures of carbon dioxide (PET CO2)(1 day)
  • Changes in arterial blood parameters(1 day)

Study Sites (1)

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