NCT03196089已完成2 期
Effect of Short-term Oxygen Therapy on Cardiopulmonary Exercise (CPET) Capacity in Patients With Chronic Obstructive Pulmonary Disease (COPD)
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Watt
研究概览
简要总结
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic obstructive pulmonary disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of chronic obstructive pulmonary disease
- •on optimized medical therapy and in stable condition for at least 4 week
- •desaturate in the 6 minute walking test by at least 4% to values <92%
排除标准
- •unstable conditions
- •pregnant women
- •patients with relevant concomitant lung disease and severe daytime hypoxemia
结局指标
主要结局
Watt
时间窗: 1 day
Exercise time
时间窗: 1 day
次要结局
- Ventilatory equivalent of carbon dioxide (VE/VCO2) slope(1 day)
- Peak Oxygen uptake(1 day)
- Respiratory Exchange ratio(1 day)
- End-tidal pressures of carbon dioxide (PET CO2)(1 day)
- Changes in arterial blood parameters(1 day)
研究者
研究点 (2)
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