Effect of Short-term Oxygen During CPET in COPD

Phase 2

Completed

• Conditions: Chronic Obstructive Pulmonary Disease

• Registration Number: NCT03196089
• Lead Sponsor: University of Zurich

Brief Summary

In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with chronic obstructive pulmonary disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-02
• Study First Submitted: 2017-06-20
• Study First Submitted QC: 2017-06-20
• Study First Posted: 2017-06-22
• Primary Completion: 2018-12-31
• Study Completion: 2018-12-31
• Status Verified: 2019-08
• Last Update Submitted: 2019-08-12
• Last Update Posted: 2019-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• diagnosis of chronic obstructive pulmonary disease
• on optimized medical therapy and in stable condition for at least 4 week
• desaturate in the 6 minute walking test by at least 4% to values <92%

Exclusion Criteria

• unstable conditions
• pregnant women
• patients with relevant concomitant lung disease and severe daytime hypoxemia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Watt	1 day
Exercise time	1 day

Secondary Outcome Measures

Name	Time	Method
Ventilatory equivalent of carbon dioxide (VE/VCO2) slope	1 day
Peak Oxygen uptake	1 day
Respiratory Exchange ratio	1 day
End-tidal pressures of carbon dioxide (PET CO2)	1 day
Changes in arterial blood parameters	1 day

Trial Locations

Locations (1)

University Hospital Zurich, Division of Pneumology; 🇨🇭 Zürich, Switzerland