Passive Leg Raising - an Important Diagnostic Manoeuvre and Its Dependency on the Activity of the Autonomous Nervous System in Critically Ill Patients and Healthy Subjects
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiovascular Insufficiency
- Sponsor
- Region MidtJylland Denmark
- Enrollment
- 11
- Locations
- 1
- Primary Endpoint
- Changes in HRV frequency domain variables V
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The aim is to describe the physiological background for PLR and the interpretation of a PLR manoeuvre.
The protocol entails the measurement of stroke volume (SV) at baseline (semirecumbent patient position), during PLR and after returning to semirecumbent position. Simultaneously blood pressure (BP), pulse rate (PR), pulse oximetric saturation (SpO2) and ECG are recorded. The procedure is performed in ten normal subjects, ten patients recruited in the cardiology outpatient department and ten critically ill patients under analgosedation in the ICU.
Analysis includes changes in measured variables and heart rate variability in the frequency domain during the three phases of the experiment.
Detailed Description
See above
Investigators
Soren Sondergaard
Senior Consultant, MD, PhD
Region MidtJylland Denmark
Eligibility Criteria
Inclusion Criteria
- •Consenting after written and oral information
Exclusion Criteria
- •Contraindications to PLR: intracranial or abdominal hypertension
Outcomes
Primary Outcomes
Changes in HRV frequency domain variables V
Time Frame: 10 minutes
Heart rate variability, HRV, variables in frequency domain (low frequency, LF, 0.04-0.15 Hz, high frequency, HF, 0.15-0.4 Hz)
Changes in HRV frequency domain variables VIII
Time Frame: 10 minutes
HRV normalized power (%, normalized units, n.u.)
Changes in cardiovascular variables I
Time Frame: 10 minutes
stroke volume, SV (mL)
Changes in cardiovascular variables III
Time Frame: 10 minutes
blood pressure, BP (mmHg)
Changes in cardiovascular variables II
Time Frame: 10 minutes
pulse rate, PR (min\^-1)
Changes in HRV frequency domain variables VII
Time Frame: 10 minutes
HRV relative power (absolute power/total power)
Changes in HRV frequency domain variables IX
Time Frame: 10 minutes
HRV total power given by VLF + HF + LF (ms2) and LF/HF ratio.
Changes in cardiovascular variables IV
Time Frame: 10 minutes
pulse oximetric saturation, SpO2 (%)
Changes in HRV frequency domain variables VI
Time Frame: 10 minutes
HRV absolute power (ms\^2, natural logarithm transformed values of absolute powers of very low frequency, VLF, LF, and HF bands)