Passive Leg Raising - an Important Diagnostic Manoeuvre and Its Dependency on the Activity of the Autonomous Nervous System in Critically Ill Patients and Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Changes in HRV frequency domain variables V
研究概览
简要总结
The aim is to describe the physiological background for PLR and the interpretation of a PLR manoeuvre.
The protocol entails the measurement of stroke volume (SV) at baseline (semirecumbent patient position), during PLR and after returning to semirecumbent position. Simultaneously blood pressure (BP), pulse rate (PR), pulse oximetric saturation (SpO2) and ECG are recorded. The procedure is performed in ten normal subjects, ten patients recruited in the cardiology outpatient department and ten critically ill patients under analgosedation in the ICU.
Analysis includes changes in measured variables and heart rate variability in the frequency domain during the three phases of the experiment.
详细描述
See above
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Consenting after written and oral information
排除标准
- •Contraindications to PLR: intracranial or abdominal hypertension
结局指标
主要结局
Changes in HRV frequency domain variables V
时间窗: 10 minutes
Heart rate variability, HRV, variables in frequency domain (low frequency, LF, 0.04-0.15 Hz, high frequency, HF, 0.15-0.4 Hz)
Changes in HRV frequency domain variables VIII
时间窗: 10 minutes
HRV normalized power (%, normalized units, n.u.)
Changes in cardiovascular variables I
时间窗: 10 minutes
stroke volume, SV (mL)
Changes in cardiovascular variables III
时间窗: 10 minutes
blood pressure, BP (mmHg)
Changes in cardiovascular variables II
时间窗: 10 minutes
pulse rate, PR (min\^-1)
Changes in HRV frequency domain variables VII
时间窗: 10 minutes
HRV relative power (absolute power/total power)
Changes in HRV frequency domain variables IX
时间窗: 10 minutes
HRV total power given by VLF + HF + LF (ms2) and LF/HF ratio.
Changes in cardiovascular variables IV
时间窗: 10 minutes
pulse oximetric saturation, SpO2 (%)
Changes in HRV frequency domain variables VI
时间窗: 10 minutes
HRV absolute power (ms\^2, natural logarithm transformed values of absolute powers of very low frequency, VLF, LF, and HF bands)
次要结局
未报告次要终点
研究者
Soren Sondergaard
Senior Consultant, MD, PhD
Region MidtJylland Denmark