The effect of melatonin on interleukin 6 & interleukin 9 in coronary artery bypass grafting surgery
Phase 2
- Conditions
- Coronary Artery Bypass Surgery.Atherosclerotic heart disease of native coronary artery
- Registration Number
- IRCT20141009019470N72
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
Patients who are candidate for elective CABG
age between 40-75 years old
ASA class pump time less than 90 min;
graft number between 2 to 6
Exclusion Criteria
pregnancy
local or systemic infection
hyper sensitivity
redo surgery
surgery during last 6 months
collagen vascular disease
immunosuppressive disease
heart failure with ejection fraction less than 35%
recent cardiovascular event
renal failure
alcohol abuser
simultaneously valvular heart surgery
uncontrolled HTN
liver failure
breast feeding
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum level of interleukin 6 and interleukin 9. Timepoint: two weeks before administration of melatonin, in the operating room before induction of anesthesia, 6 hours after declamping in the ICU and 48 hours after off pump. Method of measurement: venous blood samples.
- Secondary Outcome Measures
Name Time Method