The Effect of Melatonin on interleukin in patients undergoing Coronary Artery Bypass Graft Surgery

Phase 2

• Conditions: Coronary Artery Bypass Surgery.; Atherosclerotic heart disease of native coronary artery

• Registration Number: IRCT20141009019470N71
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 March 2018

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

En Patients who are candidate for elective CABG
Age between 40-75 years old
ASA class Pump time less than 90 min; graft number between 2 to 6.
Graft number between 2 to 6.

Exclusion Criteria

pregnancy and breast feeding
local or systemic infection
hyper sensitivity
redo surgery
surgery during last 6 months
collagen vascular disease
immunosuppressive disease
heart failure with ejection fraction less than 35%
recent cardiovascular event
uncontrolled HTN
renal failure
liver failure
alcohol abuser
malignancy
simultaneously valvular heart surgery.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum level of interleukin 13. Timepoint: two weeks before administration of melatonin, in the operating room before induction of anesthesia, 6 hours after declamping in the ICU and 48 hours after off pump. Method of measurement: venous blood samples.;Serum level of interleukin 22. Timepoint: two weeks before administration of melatonin, in the operating room before induction of anesthesia, 6 hours after declamping in the ICU and 48 hours after off pump. Method of measurement: venous blood samples.