Effect of Melatonin in brain injury
- Conditions
- Brain injury.Intracranial injury
- Registration Number
- IRCT20081208001497N8
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Adult patients (age more than 18) who had traumatic brain injury included skull fracture, subdural hemorrhage, subarachnoid hemorrhage, brain contusion and laceration, intracerebral hemorrhage, intraventricular hemorrhage and traumatic axonal injury
Non-traumatic brain injury included strokes, infections, hypoxia and brain tumors
Admission within 72 hours after brain injury in intensive care unit or other wards such as neurology or neurosurgery
Healthy gastrointestinal tract (capable of oral ingestion or gavage of drug)
Length of hospitalization less than 5 days in intensive care units or other wards
Hypersensitivity to melatonin
Hepatic failure (class C according to Child-pugh)
Renal failure (need dialysis)
Severe heart failure (Class 3 and 4 according to Newyork heart association)
Sepsis within first 5 days of admission
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in bio markers of mitochondrial injury. Timepoint: Day 1 and 5 of intervention. Method of measurement: Elisa kit.
- Secondary Outcome Measures
Name Time Method Mortality rate of patients. Timepoint: 28 days. Method of measurement: Observation.