SteepRamp validation & tendon structure in DM2.
- Conditions
- Diabetes Mellitus type 2
- Registration Number
- NL-OMON28345
- Lead Sponsor
- Erasmus MC, Universitair Medisch Centrum RotterdamAfdeling Revalidatie geneeskunde / SportgeneeskundeIntern adres: Kamer H. 026postbus 20403000 CA RotterdamNederland
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 165
Inclusion Criteria
Substudy A:
1. Type 2 diabetes mellitus >2 yr;
Exclusion Criteria
Substudy A and B:
1. Cardiovascular disease such as heart failure, cardiac ischemia or serious peripheral vascular disease (e.g. claudicatio intermittens);
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Substudy A:<br /><br>Validating the supramaximal SteepRamp exercise test to determine physical fitness in type 2 diabetes patients by correlating the result with a conventional VO2max exercise test and determining the test-retest reliability.<br><br /><br /><br>Substudy B:<br>Comparing Achilles tendinosis incidence in type 2 diabetes patients with the incidence in matched controls.<br>
- Secondary Outcome Measures
Name Time Method Substudy A:<br /><br>1. Develop a regression formula to predict VO2max, daily activity pattern and quadriceps strength from SteepRamp test results in type 2 diabetes patients;<br /><br>2. Obtaining reference values for physical fitness, activity pattern en quadriceps strength for type 2 diabetes patients;<br /><br>3. Correlating physical fitness with the level of AGE in type 2 diabetes patients.<br><br /><br /><br>Substudy B:<br /><br>1. Correlating muscle strength and activity pattern with Achilles tendon structure abnormalities in type 2 diabetes patients;<br /><br>2. Correlating advanced glycation end-products (AGE) with Achilles tendon structure abnormalities in type 2 diabetes patients.<br>