To identify the pathogenesis of COVID-19 at different stages with the help of Ayurveda

Not yet recruiting

• Conditions: Coronavirus infection, unspecified,

• Registration Number: CTRI/2020/08/027494
• Lead Sponsor: All India Institute of Ayurveda

Brief Summary

Global community is facing anunprecedented pandemic of novel coronavirus disease (COVID-19) caused by SevereAcute Respiratory Syndrome -  Coronavirus2 (SARS-CoV- 2). The pandemic is continuing to spread and the need of  a clinically-proven prophylaxis andtherapeutic strategy is evident .  Thedimensions of pandemic require an urgent harnessing of all knowledge systemsavailable globally.

Ayurveda has enough potential andpossibilities to be employed both for prevention and treatment of COVID-19.Therefore , there is an urgent need to understand the pathophysiology of themorbidity so that an effective management can be planned accordingly .  Another substantial question is “ why somepatients with the virus do very well whereas others need to be admitted tointensive care and may die from the disease.â€[1]

Why does the response to the sameetiological factor  ;  vary from individual to individual?

Along with that severity of diseaseis closely related to the prognosis, the basic and essential strategies toimprove outcomes that we should adhere to remain the early detection ofhigh-risk and critically ill patients. Probing into such questions can redefinethe pathogenesis of the morbidity through a new dimension .

 1.2 Relevance of the work

 This observational  study is an attempt to trace the pathologicalmodels of COVID 19 framed on the principles of *Ayurveda*.   The frameworksplay an instrumental  role in theprogression and manifestation of the disease. In this particular study , theresearchers will be focussing on two basic models which are as follows :

*1)**Shat - kriyakala*

2)    *Vikar vighata - bhava ; abhava ( Nidana ,dosha , dushya* paradigm )

 1) Pathological model 1 - *Shat kriya kala*

The term *Kriyakala* refers to the recognition of the stage of a disease  progress, which helps to determine appropriatemeasures to correct the imbalance in *Doshas*. It is defined as a  compoundexpression, composed of *Kriya* and *Kala*, where *Kriya* means the intervention of choice and *kala* refers to the stage of progress of a disease. [2]

 2) Pathological model 2 -  *Vikarvighata - bhava ; abhava ( Nidana , dosha , dushya* paradigm )

“Diagnosis†in *Ayurveda* is in terms of the nature or the phenomenon of thedisease. This phenomenon is described in terms of the *Samprapti* (pathogenesis) of the disease in each patient, comprising*Dosha, Dushya* and *Adhisthana* components .[3] The specificinteraction of etiological factors with *doshas*and *dushyas*, as well as the presenceor absence of disease-resisting factors (individual’s immunity or ability toresist the disease), influence the outcome regarding the manifestation of adisease  It is stated that if theinteraction of etiological factors, *doshasand dushyas* are weak and these are antagonistic to each other, and if theinfluence of temporal factors (time or seasonal influence) are also weak, theneither the **disease does not manifest**,**or there is a delay in manifestation ofthe disease.**[4]  In such cases, evenif there is an onset of the disease, its severity could be low, or all of itssigns and symptoms may not manifest. Thus, the presence or absence of specificfactors determine the ability or otherwise of the body to resist all types ofdiseases.

Recent studies have reported thatthe severity of the disease is a function of individual immune response to thevirus.The response is a function of 3 factors - *Hetu ; Dosha ; Dushya* .[5] The permutation and combination of the three variables in a particularbody type can give a direction to the manifestation and progression of thedisease.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-09
• Last Update Posted: 2020-08-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Patients >20 yrs.
• SARS COV-2 confirmed by RT PCR/RAD Mild to moderate category patients with potential risk factor Patient willing to participate.

Exclusion Criteria

Patient unwilling to take part Unconscious patient.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To validate concept of shatkriyakala and vikara vighat bhava abhava in pathogenesis of covid-19	2 MONTHS

Secondary Outcome Measures

Name	Time	Method
To validate concept of shatkriyakala and vikara vighat bhava abhava in pathogenesis of covid-19	4 months

Trial Locations

Locations (1)

All INDIA INSTITUTE OF AYURVEDA; 🇮🇳 South, DELHI, India

All INDIA INSTITUTE OF AYURVEDA

🇮🇳South, DELHI, India

Dr Sisir Kumar Mandal

Principal investigator

8697097984

todrskmandal@gmail.com