FactORs prEdiCting the trAnsition from acute to persistent pain in people with ‘SciaTica’-the FORECAST longitudinal prognostic factor cohort, a substudy of the PiPL platform

niversity of Oxford0 sites180 target enrollmentFebruary 10, 2023

Overview

2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37019481/ (added 06/04/2023)

Registry

who.int

Start Date

February 10, 2023

End Date

August 30, 2025

Last Updated

last year

Study Type

Observational

Sex

All

Sponsor

•1\. People aged \>18 years with a clinical diagnosis of ‘sciatica’
•2\. Sciatica symptom onset of the current episode within the past three months with a symptom\-free period of at least 3 months preceding the current sciatica symptoms
•3\. A sum score of \>4 (on the diagnostic model published by Stynes 2018\) will be defined as sciatica (weighted sum score including self\-reported sensory changes, below knee pain, leg pain worse than back pain, neurodynamic tests, and neurological deficit)
•4\. Clinical examination confirms the clinical diagnosis of sciatica and rules out other diagnoses

•1\. Presence of other nerve\-related disorders (e.g. diabetic neuropathy, stroke)
•2\. Previous lumbar spine surgery
•3\. Serious spinal pathologies (e.g. infection, cauda equina syndrome, metastatic lesions)
•4\. Chronic inflammatory disorders
•5\. Other pain conditions that may confound assessment (e.g., fibromyalgia)
•6\. Pregnancy
•7\. Insufficient command of the English language to obtain consent/complete questionnaires
•8\. Contraindications to MRI for those selected for scanning