Diclofenac for Achilles tendinopathy

Not Applicable

Completed

Conditions: Achilles tendinopathy
Musculoskeletal Diseases

Registration Number: ISRCTN60151284

Lead Sponsor: niversity of British Columbia

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 32

Inclusion Criteria

1. Male and female subjects aged 19 years and older
2. Fluent in English
3. Subjects previously diagnosed with Achilles tendinopathy by a health care professional and demonstrating the following criteria – localized tendon pain and thickening, worsened with palpation and tendon loading activities, and no clinical suspicion of other diagnoses
4. Symptoms for 3 months or more
5. Subjects who are able to give informed consent
6. VISA-A score less than 80
7. Pain score (numeric pain rating scale) greater than 2/10 when performing a hopping test (25 single leg hops on the painful side)

Exclusion Criteria

1. Male and female subjects aged 18 years and younger
2. Subjects with a BMI greater than 30.0
3. Subjects with previous Achilles tendon rupture
4. Subjects diagnosed with pain syndrome, diabetes, hyperproteinemia, metabolic syndrome, or systemic inflammatory diseases
5. Subjects with symptomatic osteoarthritis of the spine or lower extremities
6. Subjects who have received corticosteroid injections
7. Subjects who take non-steroidal anti-inflammatory medication regularly
8. Subjects who have been prescribed statins, anticoagulant, or fluroquinolones within the past 3 months
9. Subjects with allergies to diclofenac or placebo cream
10. Subjects who are unable to give informed consent

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measured at baseline, 1 week, day 10, and day 23 <br> <br>Assessment of tendon pain while performing 25 single-leg hops on the painful side, rated verbally using the numeric pain rating scale. The hopping test consists of 25 rhythmic hops, at a self-selected/comfortable pace (approx. 2 jumps/second), on one leg, first on the unaffected side, and then on the affected side (15 second rest between each leg). ). At the end of the hopping, the subject’s pain level will be recorded using a pain numeric rating scale (0-10).

Secondary Outcome Measures