The Combination of Sperm Selection by IMSI and Hyaluronic Acid Binding Assay May Improve ICSI Outcome.
- Conditions
- Fertility Issues
- Interventions
- Procedure: Sperm selection by IMSIProcedure: Sperm selection by IMSI and spermslow
- Registration Number
- NCT06156722
- Lead Sponsor
- Meir Medical Center
- Brief Summary
In this prospective randomized sibling-oocytes blinded study, investigators examine the combination of two sperm selection methods that logically seem to complete each other, and potentially may improve ICSI outcomes.
The methods include the selection of the optimal spermatozoa based on its morphology by IMSI, together with its physiological function of binding to HA by Spermslow (SS).
The current study compared a group of ET after sperm selection by IMSI with SS to a group of ET after sperm selection by IMSI-only without SS, and to a mixed ET group where two embryos were transferred, one after IMSI-only and the other one after IMSI with SS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- Female
- Target Recruitment
- 189
females ages 38 or younger retrieval of at least 5 mature oocytes and fresh ejaculate samples
frozen embryos surgically extracted sperm preparations embryo-biopsy cycles
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description The IMSI-only group Sperm selection by IMSI The IMSI-only group IMSI with SpermSlow group Sperm selection by IMSI and spermslow IMSI with SpermSlow group
- Primary Outcome Measures
Name Time Method Pregnancy and delivery rates Within up to 10 month from treatment Pregnancy and delivery rates
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Meir Medical Center
🇮🇱Kfar Saba, Israel