The Combination of Sperm Selection by IMSI and Hyaluronic Acid Binding Assay Improves ICSI Outcomes: A Randomized Prospective Sibling-oocytes Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 189
- 试验地点
- 1
- 主要终点
- Pregnancy and delivery rates
研究概览
简要总结
In this prospective randomized sibling-oocytes blinded study, investigators examine the combination of two sperm selection methods that logically seem to complete each other, and potentially may improve ICSI outcomes.
The methods include the selection of the optimal spermatozoa based on its morphology by IMSI, together with its physiological function of binding to HA by Spermslow (SS).
The current study compared a group of ET after sperm selection by IMSI with SS to a group of ET after sperm selection by IMSI-only without SS, and to a mixed ET group where two embryos were transferred, one after IMSI-only and the other one after IMSI with SS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •females ages 38 or younger retrieval of at least 5 mature oocytes and fresh ejaculate samples
排除标准
- •frozen embryos surgically extracted sperm preparations embryo-biopsy cycles
结局指标
主要结局
Pregnancy and delivery rates
时间窗: Within up to 10 month from treatment
Pregnancy and delivery rates
次要结局
未报告次要终点
研究者
Yael Yagur
Consultant, Obstetrics and Gynaecology Department. Principal investigator. Lecturer.
Meir Medical Center