Comparison of effect of Letrozole or Leuprolide for preparing the endometrium(lining of uterus) before transferring frozen embryos

Phase 4

Not yet recruiting

Conditions: Infertility

Registration Number: CTRI/2018/05/013894

Lead Sponsor: AIIMSDelhi

Brief Summary: Women planned for IVF cycles will undergo pre-treatment assessment as per unit guidelines. Women undergoing IVF cycles for tubal factor, PCOS, unexplained infertility and expected to have an optimal response such that will undergo FET cycles will be recruited after a proper counseling. After embro-cryopreservation women planned for FET and meeting eligibility criteria will be randomly allocated to letrozole stimulated endometrial preparation (Group A) and GnRH-agonist HRT based endometrial preparation (Group B), through computer generated random numbers. Randomization will be done prior to the start of endometrial preparation.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: Female

Target Recruitment: 140

Inclusion Criteria

Women undergoing FET with at least 2 embryo vitrified , normal endometrial cavity and willing to participate in study.

Exclusion Criteria

Women undergoing IVF with severe male factor demanding ICSI or surgical sperm extraction , poor responders ( < 3 oocyte retrieved at ovum pick up ), adenomyosis / fibroid , uterine adhesions/uterine cavityâ€™s unsuitable for IVF FET at pre IVF WORKUP, donor oocyte cycle.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)Clinical pregnancy rate 2)ongoing pregnancy rate	1)Clinical pregnancy rate 4wk after embryo transfer I.e 6wk POG \| 2)ongoing pregnancy rate 10 wk of embryo transfer or 12 wk POG

Secondary Outcome Measures

Name	Time	Method
1)Implantation rate. 2)endometrial thickness and pattern	1)6wk. 2) 2wk

Trial Locations

Locations (1): All India Institute of Medical Scienc(AIIMS),,Delhi
🇮🇳
Delhi, DELHI, India
All India Institute of Medical Scienc(AIIMS),,Delhi
🇮🇳Delhi, DELHI, India
Gayathri M S
Principal investigator
7838421681
dr.gayathri012@gmail.com