Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling

Not Applicable

Completed

• Conditions: Ultra-marathon Runners
• Interventions: Other: maximum effort test on a treadmill; Other: maximum effort test on a cycloergometer

• Registration Number: NCT04511858
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

The mechanisms contributing to muscle fatigue in extreme long-duration exercise bouts are poorly understood. Ultra-endurance exercise is an excellent model for the study of adaptive responses to extreme loads and stress and it is an especially useful model for documenting the origins of central fatigue. This protocol will compare fatigue during and after ultra-endurance exercise bouts that result in moderate lower-limb tissue damage (i.e. cycling) or significant damage (i.e. running). The results of this protocol will allow us to further understanding of the reasons for major central fatigue, i.e. within the central nervous system, in ultra-endurance.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-07-31
• Study First Submitted QC: 2020-08-11
• Study First Posted: 2020-08-13
• Study Start: 2021-03-05
• Primary Completion: 2021-05-28
• Study Completion: 2021-07-15
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-23
• Last Update Posted: 2021-11-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 19

Inclusion Criteria

• Specialist in endurance and ultra-endurance. in the 2 disciplines: running and cycling (triathletes, duathletes or trailers achieving at least 30% of their training volume in cycling), and having at least finished one long distance event in the last 2 years,
• Affiliated or beneficiary of a social security scheme.
• Signature of the consent form

Exclusion Criteria

• Any subject who has been injured in the 3 months prior to the protocol

• Anyone with chronic joint pathologies (e.g.: repetitive sprains, patellar or ligament problems).

• Any subject with chronic or central neurological pathologies

• Any subject with a contraindication to magnetic stimulation

• Use of neuro-active substances likely to alter cortico-spinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) on the study.

• Contraindication to the application of a magnetic field:

  • Heart or respiratory insufficiency.
  • Subject with a cardiac pace maker.
  • Cardiac valve wear and serious cardiovascular diseases.
  • Presence of prosthetic material or ferromagnetic foreign bodies in the head.
  • Presence of cochlear implants or ocular prosthetic material.
  • History of neurosurgical interventions.
  • Neurological diseases that may affect brain structures and cognitive abilities (e.g., intracranial tumour, multiple sclerosis, history of stroke or traumatic brain injury).
  • History of comitiality, contralateral knee disease or musculoskeletal disease.

• Any subject participating at the same time in another interventional experiment requiring physical exercise.

• Any subject who has taken corticosteroids within 3 months (inhalation, infiltration or history of prolonged corticosteroid therapy).

• Any subject under guardianship or curatorship

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Running endurance	maximum effort test on a treadmill	Athletes wiil run for 5 hours in a row.
Cycling endurance	maximum effort test on a cycloergometer	Athletes wiil cycle for 5 hours in a row.

Primary Outcome Measures

Name	Time	Method
Maximum level of voluntary activation of relative central fatigue	Before and immediately after 5h exercise	measured in isometric mode of the knee extensors, between the value before and immediately after a 5-hour cycling or running event at the same relative intensity

Secondary Outcome Measures

Name	Time	Method
Maximum level of voluntary activation of fatigue centrale absolute	Before and immediately after 5h exercise	measured in isometric mode of the knee extensors, between the value before the 5h cycling or running and the value after absolute exhaustion
Cortical excitability	Before and immediately after 5h exercise	ratio between stimulation of the motor cortex and thoracic spine stimulation
Measurement of isometric force values	Before and immediately after 5h exercise	subjects sitting on a Cybex type seat, with the knee and hip angle set at 90°. The foot will be attached to a strain-gauge sensor using a velcro strap attached to the ankle above the medial malleolus.
Platelets	Before and immediately after 5h exercise	blood sample
Hemoglobin	Before and immediately after 5h exercise	blood sample
C-reactive protein	Before and immediately after 5h exercise	blood sample
Maximum level of voluntary activation with electrical evoked activation	Before and immediately after 5h exercise	tests with measurement of the maximum voluntary with evoked electrical between the value before and immediately after a 5-hour cycling or running event at the same relative intensity
Spinal excitability	Before and immediately after 5h exercise	thoracic spine stimulation for the recording of thoracic motor evoked potentials
Red blood cells	Before and immediately after 5h exercise	blood sample
Measurement of the time maintained at the speed corresponding to the 2nd ventilatory threshold	Before and immediately after 5h exercise	On treadmill
Corticospinal excitability	Before and immediately after 5h exercise	stimulation of the motor cortex for recording motor evoked potentials
Measurement of speed, force and power values	Before and immediately after 5h exercise	assessment of fatigue in dynamic mode (calculation of the force/speed profile)
Mean corpuscular hemoglobin concentration	Before and immediately after 5h exercise	blood sample
Creatine PhosphoKinase	Before and immediately after 5h exercise	blood sample
Interleukines	Before and immediately after 5h exercise	blood sample
White blood cells	Before and immediately after 5h exercise	blood sample
Lactate	Before and immediately after 5h exercise	blood sample
measurement of the time maintained at the power corresponding to the 2nd ventilatory threshold	Before and immediately after 5h exercise	On Cycloergometer

Trial Locations

Locations (1)

CHU Saint-Etienne; 🇫🇷 Saint-Étienne, France